Intralumenal sarcoplasmic reticulum Ca(2+)-binding proteins.

S. E. Cala, B. T. Scott, Larry Jones

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

The sarcoplasmic reticulum (SR) controls the level of intracellular Ca2+ in cardiac and skeletal muscle by storing and releasing Ca2+. A set of intralumenal SR Ca(2+)-binding proteins has been identified that may serve important roles in SR Ca2+ storage and mobilization. The most prominent of these SR proteins, calsequestrin, is discretely localized to junctional SR. Other intralumenal proteins are more widely distributed throughout the SR. All of these intralumenal SR Ca(2+)-binding proteins are acidic, stain blue with dye Stains-All, and appear to be substrates for casein kinase II. The biochemistry and cell biology of lumenal SR proteins may conform to a paradigm now emerging from the study of endoplasmic reticulum proteins.

Original languageEnglish
Pages (from-to)265-275
Number of pages11
JournalSeminars in Cell Biology
Volume1
Issue number4
StatePublished - Aug 1990

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Sarcoplasmic Reticulum
Proteins
Coloring Agents
Calsequestrin
Casein Kinase II
Ca-binding protein 2
Endoplasmic Reticulum
Biochemistry
Cell Biology
Myocardium
Skeletal Muscle

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Intralumenal sarcoplasmic reticulum Ca(2+)-binding proteins. / Cala, S. E.; Scott, B. T.; Jones, Larry.

In: Seminars in Cell Biology, Vol. 1, No. 4, 08.1990, p. 265-275.

Research output: Contribution to journalArticle

Cala, S. E. ; Scott, B. T. ; Jones, Larry. / Intralumenal sarcoplasmic reticulum Ca(2+)-binding proteins. In: Seminars in Cell Biology. 1990 ; Vol. 1, No. 4. pp. 265-275.
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