Intramural papilloma of the vagina: Evidence of Mullerian histogenesis

Thomas Ulbright, R. W. Alexander, F. T. Kraus

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

A papillary tumor occurred in the posterior-superior vaginal wall of a 5-year-old girl who was free of recurrence one year following surgical excision. The light microscopic features included papillae lined by eosinophilic cells with uniform, bland nuclei, solid areas of identical cells, and scattered glandular lumina which contained mucopolysaccharides. Foci of eosinophilic hyaline globulines were another distinctive feature. Electron microscopy of the tumor demonstrated features associated with mullerian neoplasms including projecting microvilli, whorls of perinuclear cytoplasmic microfilaments, conspicuous lysosomes, squamous metaplasia, complex cytoplasmic interdigitations, and pseudoinclusions of 'cytoplasmic' collagen. Previously described 'mesonephric papillomas' of the vagina and cervix are compared with the tumor of the authors' patient. The previously described tumors share some histologic and clinical features, although they were superficial rather than intramural proliferations. The authors conclude that the ultrastructure, location, and documented presence of mullerian structures in the vagina favor a mullerian origin for this vaginal tumor. A number of other vaginal tumors that occur in children and young women show different light microscopic features.

Original languageEnglish (US)
Pages (from-to)2260-2266
Number of pages7
JournalCancer
Volume48
Issue number10
StatePublished - 1981
Externally publishedYes

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Papilloma
Vagina
Neoplasms
Light
Hyalin
Metaplasia
Microvilli
Lysosomes
Glycosaminoglycans
Actin Cytoskeleton
Cervix Uteri
Electron Microscopy
Collagen
Recurrence

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Ulbright, T., Alexander, R. W., & Kraus, F. T. (1981). Intramural papilloma of the vagina: Evidence of Mullerian histogenesis. Cancer, 48(10), 2260-2266.

Intramural papilloma of the vagina : Evidence of Mullerian histogenesis. / Ulbright, Thomas; Alexander, R. W.; Kraus, F. T.

In: Cancer, Vol. 48, No. 10, 1981, p. 2260-2266.

Research output: Contribution to journalArticle

Ulbright, T, Alexander, RW & Kraus, FT 1981, 'Intramural papilloma of the vagina: Evidence of Mullerian histogenesis', Cancer, vol. 48, no. 10, pp. 2260-2266.
Ulbright, Thomas ; Alexander, R. W. ; Kraus, F. T. / Intramural papilloma of the vagina : Evidence of Mullerian histogenesis. In: Cancer. 1981 ; Vol. 48, No. 10. pp. 2260-2266.
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