Intraocular pressure-lowering efficacy of bimatoprost 0.03% and travoprost 0.004% in patients with glaucoma or ocular hypertension

L. B. Cantor, J. Hoop, L. Morgan, D. WuDunn, Y. Catoira, Thomas Bournias, Louis Cantor, Monte Dirks, Efraim Duzman, Arash Mansouri, Thomas Mundorf, Steven Simmons, Robert Williams

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

Aim: To evaluate the efficacies of bimatoprost and travoprost for lowering of intraocular pressure (IOP) for the treatment of glaucoma and ocular hypertension. Methods: Prospective, randomised, investigator-blinded, parallel-group clinical trial. After completing a washout of all glaucoma drugs, patients (n = 157) were randomised to bimatoprost or travoprost for 6 months. Visits were at baseline, 1 week, and 1, 3 and 6 months. IOP was measured at 09:00 h at each visit and also at 13:00 and 16:00 h at baseline and at 3 and 6 months. Results: No significant between-group differences were observed in IOP at baseline, at 09:00, 13:00 or 16:00 h (p≥0.741). After 6 months, both drugs significantly reduced IOP at every time point (p≤0.001). After 6 months, mean IOP reduction at 09:00 h was 7.1 mm Hg (27.9%) with bimatoprost (n = 76) and 5.7 mm Hg (23.3%) with travoprost (n = 81; p = 0.014). At 13:00 h, mean IOP reduction was 5.9 mm Hg with bimatoprost (25.3%) and 5.2 mm Hg (22.4%) with travoprost (p = 0.213). At 16:00 h, the mean IOP reduction was 5.3 mm Hg (22.5%) with bimatoprost and 4.5 mm Hg (18.9%; p = 0.207) with travoprost. Both study drugs were well tolerated, with ocular redness the most commonly reported adverse event in both treatment groups. Conclusions: Bimatoprost provided greater mean IOP reductions than travoprost.

Original languageEnglish (US)
Pages (from-to)1370-1373
Number of pages4
JournalBritish Journal of Ophthalmology
Volume90
Issue number11
DOIs
StatePublished - Nov 1 2006

    Fingerprint

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Cantor, L. B., Hoop, J., Morgan, L., WuDunn, D., Catoira, Y., Bournias, T., Cantor, L., Dirks, M., Duzman, E., Mansouri, A., Mundorf, T., Simmons, S., & Williams, R. (2006). Intraocular pressure-lowering efficacy of bimatoprost 0.03% and travoprost 0.004% in patients with glaucoma or ocular hypertension. British Journal of Ophthalmology, 90(11), 1370-1373. https://doi.org/10.1136/bjo.2006.094326