Intraoperative fluorescence-guided resection of high-grade gliomas

A comparison of the present techniques and evolution of future strategies

Yiping Li, Roberto Rey-Dios, David W. Roberts, Pablo A. Valdés, Aaron Cohen-Gadol

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Objective Fluorescence guidance has a demonstrated potential in maximizing the extent of high-grade glioma resection. Different fluorophores (fluorescent biomarkers), including 5-aminolevulinic acid (5-ALA) and fluorescein, have been examined with the use of several imaging techniques. Our goal was to review the state of this technology and discuss strategies for more widespread adoption. Methods We performed a Medline search using the key words "fluorescence, " "intraoperative fluorescence-guided resection," "intraoperative image-guided resection," and "brain glioma" for articles from 1960 until the present. This initial search revealed 267 articles. Each abstract and article was reviewed and the reference lists from select articles were further evaluated for relevance. A total of 64 articles included information about the role of fluorescence in resection of high-grade gliomas and therefore were selectively included for our analysis. Results 5-ALA and fluorescein sodium have shown promise as fluorescent markers in detecting residual tumor intraoperatively. These techniques have demonstrated a significant increase in the extent of tumor resection. Regulatory barriers have limited the use of 5-ALA and technological challenges have restricted the use of fluorescein and its derivatives in the United States. Limitations to this technology currently exist, such as the fact that fluorescence at tumor margins is not always reliable for identification of tumor-brain interface. Conclusions These techniques are safe and effective for increasing gross total resection. The development of more tumor-specific fluorophores is needed to resolve problems with subjective interpretation of fluorescent signal at tumor margins. Techniques such as quantum dots and polymer or iron oxide-based nanoparticles have shown promise as potential future tools.

Original languageEnglish
Pages (from-to)175-185
Number of pages11
JournalWorld Neurosurgery
Volume82
Issue number1-2
DOIs
StatePublished - 2014

Fingerprint

Glioma
Fluorescence
Aminolevulinic Acid
Fluorescein
Neoplasms
Technology
Quantum Dots
Residual Neoplasm
Brain Neoplasms
Nanoparticles
Polymers
Biomarkers
Brain

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Intraoperative fluorescence-guided resection of high-grade gliomas : A comparison of the present techniques and evolution of future strategies. / Li, Yiping; Rey-Dios, Roberto; Roberts, David W.; Valdés, Pablo A.; Cohen-Gadol, Aaron.

In: World Neurosurgery, Vol. 82, No. 1-2, 2014, p. 175-185.

Research output: Contribution to journalArticle

@article{8cf5f81c603d410ba606a460f8c6017b,
title = "Intraoperative fluorescence-guided resection of high-grade gliomas: A comparison of the present techniques and evolution of future strategies",
abstract = "Objective Fluorescence guidance has a demonstrated potential in maximizing the extent of high-grade glioma resection. Different fluorophores (fluorescent biomarkers), including 5-aminolevulinic acid (5-ALA) and fluorescein, have been examined with the use of several imaging techniques. Our goal was to review the state of this technology and discuss strategies for more widespread adoption. Methods We performed a Medline search using the key words {"}fluorescence, {"} {"}intraoperative fluorescence-guided resection,{"} {"}intraoperative image-guided resection,{"} and {"}brain glioma{"} for articles from 1960 until the present. This initial search revealed 267 articles. Each abstract and article was reviewed and the reference lists from select articles were further evaluated for relevance. A total of 64 articles included information about the role of fluorescence in resection of high-grade gliomas and therefore were selectively included for our analysis. Results 5-ALA and fluorescein sodium have shown promise as fluorescent markers in detecting residual tumor intraoperatively. These techniques have demonstrated a significant increase in the extent of tumor resection. Regulatory barriers have limited the use of 5-ALA and technological challenges have restricted the use of fluorescein and its derivatives in the United States. Limitations to this technology currently exist, such as the fact that fluorescence at tumor margins is not always reliable for identification of tumor-brain interface. Conclusions These techniques are safe and effective for increasing gross total resection. The development of more tumor-specific fluorophores is needed to resolve problems with subjective interpretation of fluorescent signal at tumor margins. Techniques such as quantum dots and polymer or iron oxide-based nanoparticles have shown promise as potential future tools.",
author = "Yiping Li and Roberto Rey-Dios and Roberts, {David W.} and Vald{\'e}s, {Pablo A.} and Aaron Cohen-Gadol",
year = "2014",
doi = "10.1016/j.wneu.2013.06.014",
language = "English",
volume = "82",
pages = "175--185",
journal = "World Neurosurgery",
issn = "1878-8750",
publisher = "Elsevier Inc.",
number = "1-2",

}

TY - JOUR

T1 - Intraoperative fluorescence-guided resection of high-grade gliomas

T2 - A comparison of the present techniques and evolution of future strategies

AU - Li, Yiping

AU - Rey-Dios, Roberto

AU - Roberts, David W.

AU - Valdés, Pablo A.

AU - Cohen-Gadol, Aaron

PY - 2014

Y1 - 2014

N2 - Objective Fluorescence guidance has a demonstrated potential in maximizing the extent of high-grade glioma resection. Different fluorophores (fluorescent biomarkers), including 5-aminolevulinic acid (5-ALA) and fluorescein, have been examined with the use of several imaging techniques. Our goal was to review the state of this technology and discuss strategies for more widespread adoption. Methods We performed a Medline search using the key words "fluorescence, " "intraoperative fluorescence-guided resection," "intraoperative image-guided resection," and "brain glioma" for articles from 1960 until the present. This initial search revealed 267 articles. Each abstract and article was reviewed and the reference lists from select articles were further evaluated for relevance. A total of 64 articles included information about the role of fluorescence in resection of high-grade gliomas and therefore were selectively included for our analysis. Results 5-ALA and fluorescein sodium have shown promise as fluorescent markers in detecting residual tumor intraoperatively. These techniques have demonstrated a significant increase in the extent of tumor resection. Regulatory barriers have limited the use of 5-ALA and technological challenges have restricted the use of fluorescein and its derivatives in the United States. Limitations to this technology currently exist, such as the fact that fluorescence at tumor margins is not always reliable for identification of tumor-brain interface. Conclusions These techniques are safe and effective for increasing gross total resection. The development of more tumor-specific fluorophores is needed to resolve problems with subjective interpretation of fluorescent signal at tumor margins. Techniques such as quantum dots and polymer or iron oxide-based nanoparticles have shown promise as potential future tools.

AB - Objective Fluorescence guidance has a demonstrated potential in maximizing the extent of high-grade glioma resection. Different fluorophores (fluorescent biomarkers), including 5-aminolevulinic acid (5-ALA) and fluorescein, have been examined with the use of several imaging techniques. Our goal was to review the state of this technology and discuss strategies for more widespread adoption. Methods We performed a Medline search using the key words "fluorescence, " "intraoperative fluorescence-guided resection," "intraoperative image-guided resection," and "brain glioma" for articles from 1960 until the present. This initial search revealed 267 articles. Each abstract and article was reviewed and the reference lists from select articles were further evaluated for relevance. A total of 64 articles included information about the role of fluorescence in resection of high-grade gliomas and therefore were selectively included for our analysis. Results 5-ALA and fluorescein sodium have shown promise as fluorescent markers in detecting residual tumor intraoperatively. These techniques have demonstrated a significant increase in the extent of tumor resection. Regulatory barriers have limited the use of 5-ALA and technological challenges have restricted the use of fluorescein and its derivatives in the United States. Limitations to this technology currently exist, such as the fact that fluorescence at tumor margins is not always reliable for identification of tumor-brain interface. Conclusions These techniques are safe and effective for increasing gross total resection. The development of more tumor-specific fluorophores is needed to resolve problems with subjective interpretation of fluorescent signal at tumor margins. Techniques such as quantum dots and polymer or iron oxide-based nanoparticles have shown promise as potential future tools.

UR - http://www.scopus.com/inward/record.url?scp=84908233470&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84908233470&partnerID=8YFLogxK

U2 - 10.1016/j.wneu.2013.06.014

DO - 10.1016/j.wneu.2013.06.014

M3 - Article

VL - 82

SP - 175

EP - 185

JO - World Neurosurgery

JF - World Neurosurgery

SN - 1878-8750

IS - 1-2

ER -