Intraoperative sponge 5-fluorouracil to reduce postoperative scarring in strabismus surgery

Justin S. Mora, Derek T. Sprunger, Eugene M. Helveston, Andrew Evan

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Introduction: To determine whether 5-fluorouracil is effective in reducing scarring after strabismus surgery we used rectus muscle surgery in experimental animals to compare a single intraoperative dose of 5-fluorouracil with mitomycin C and to compare results in similarly treated controls not receiving these antimetabolites. Methods: Muscle resections were performed on eight rabbits (16 eyes). Four eyes had 5-fluorouracil (50 mg/ml), and four eyes received mitomycin C (0.2 mg/ml), each of which was applied during surgery on an ophthalmic sponge for 5 minutes. Eight eyes served as controls. Six weeks after surgery conjunctival vascularity, muscle length-tension curves, muscle disinsertion force, and the histologic degree of scarring were assessed. Results: The mitomycin C-treated eyes clearly had more conjunctival avascularity and a lower disinsertion force. Both treated groups had flatter length-tension curves and less scarring on histologic examination than the control eyes. Conclusions: Antifibroproliferative therapy with intraoperative sponge 5-fluorouracil appears as effective as, and is possibly safer than, mitomycin C. It may be a useful adjunct in recurrent strabismus surgery or in other situations where a risk of excessive postoperative scarring exists.

Original languageEnglish
Pages (from-to)92-97
Number of pages6
JournalJournal of AAPOS
Volume1
Issue number2
StatePublished - 1997

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Strabismus
Porifera
Fluorouracil
Cicatrix
Mitomycin
Muscles
Antimetabolites
Muscle Tonus
Rabbits

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Intraoperative sponge 5-fluorouracil to reduce postoperative scarring in strabismus surgery. / Mora, Justin S.; Sprunger, Derek T.; Helveston, Eugene M.; Evan, Andrew.

In: Journal of AAPOS, Vol. 1, No. 2, 1997, p. 92-97.

Research output: Contribution to journalArticle

Mora, Justin S. ; Sprunger, Derek T. ; Helveston, Eugene M. ; Evan, Andrew. / Intraoperative sponge 5-fluorouracil to reduce postoperative scarring in strabismus surgery. In: Journal of AAPOS. 1997 ; Vol. 1, No. 2. pp. 92-97.
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