Intrapericardial ethanol delivery inhibits neointimal proliferation after porcine coronary overstretch

Dongming Hou, Ping Zhang, Alexander E. Marsh, Keith L. March

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background. Previous work has shown that ethanol dampens cell growth signals and inhibits smooth muscle proliferation in a restenosis model. Catheter-based approaches to intrapericardial (IPC) delivery of therapeutic agents have been recently demonstrated to be feasible. This study tested the effect of IPC instillation of ethanol on the injury response of overstretched porcine coronary arteries. Methods. Ethanol, 30%, (E, 10 mL, n = 6) or saline, 0.9%, (C, 10 ML, n = 6) was administered IPC after overstretch injury of porcine coronary arteries. Animals were sacrificed 28 days after balloon dilation. Results. The neointimal and adventitial area were significantly reduced in the E group (0.36 ± 0.05 mm2; 1.68 ± 0.09 mm2 ) as compared to the C group (0.61 ± 0.05 mm2; 2.61 ± 0.14 mm2; p < 0.001). The maximal intimal and adventitial thicknesses of the treated vessels were also significantly smaller than those of untreated vessels (0.44 ± 0.02,0.38 ± 0.08 mm vs 0.57 ± 0.03, 0.54 ± 0.03 mm, respectively; p<0.005). The calculated luminal stenosis decreased in the treated group, 16.1%, versus the control group, 25.3%. Conclusion. Perivascular administration of a single-dose of ethanol significantly reduce neointimal proliferation in the porcine balloon-overstretch model. This data suggests that intrapericardial delivery of therapeutic agents may be useful and feasible in the coronary angioplasty setting for prevention of restenosis.

Original languageEnglish (US)
Pages (from-to)637-642
Number of pages6
JournalJournal of the Chinese Medical Association
Volume66
Issue number11
StatePublished - Nov 1 2003

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Ethanol
Swine
Adventitia
Coronary Vessels
Tunica Intima
Wounds and Injuries
Angioplasty
Smooth Muscle
Dilatation
Pathologic Constriction
Catheters
Control Groups
Therapeutics
Growth

Keywords

  • Angioplasty
  • Ethanol
  • Restenosis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Intrapericardial ethanol delivery inhibits neointimal proliferation after porcine coronary overstretch. / Hou, Dongming; Zhang, Ping; Marsh, Alexander E.; March, Keith L.

In: Journal of the Chinese Medical Association, Vol. 66, No. 11, 01.11.2003, p. 637-642.

Research output: Contribution to journalArticle

Hou, Dongming ; Zhang, Ping ; Marsh, Alexander E. ; March, Keith L. / Intrapericardial ethanol delivery inhibits neointimal proliferation after porcine coronary overstretch. In: Journal of the Chinese Medical Association. 2003 ; Vol. 66, No. 11. pp. 637-642.
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abstract = "Background. Previous work has shown that ethanol dampens cell growth signals and inhibits smooth muscle proliferation in a restenosis model. Catheter-based approaches to intrapericardial (IPC) delivery of therapeutic agents have been recently demonstrated to be feasible. This study tested the effect of IPC instillation of ethanol on the injury response of overstretched porcine coronary arteries. Methods. Ethanol, 30{\%}, (E, 10 mL, n = 6) or saline, 0.9{\%}, (C, 10 ML, n = 6) was administered IPC after overstretch injury of porcine coronary arteries. Animals were sacrificed 28 days after balloon dilation. Results. The neointimal and adventitial area were significantly reduced in the E group (0.36 ± 0.05 mm2; 1.68 ± 0.09 mm2 ) as compared to the C group (0.61 ± 0.05 mm2; 2.61 ± 0.14 mm2; p < 0.001). The maximal intimal and adventitial thicknesses of the treated vessels were also significantly smaller than those of untreated vessels (0.44 ± 0.02,0.38 ± 0.08 mm vs 0.57 ± 0.03, 0.54 ± 0.03 mm, respectively; p<0.005). The calculated luminal stenosis decreased in the treated group, 16.1{\%}, versus the control group, 25.3{\%}. Conclusion. Perivascular administration of a single-dose of ethanol significantly reduce neointimal proliferation in the porcine balloon-overstretch model. This data suggests that intrapericardial delivery of therapeutic agents may be useful and feasible in the coronary angioplasty setting for prevention of restenosis.",
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