Intratubular germ cell neoplasms of the testis and bilateral testicular tumors

Clinical significance and management options

Michael C. Risk, Timothy Masterson

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objectives : Intratubular germ cell neoplasia (ITGCN) is the precursor lesion for invasive testicular germ cell tumors (TGCTs) of adolescents and young adults. The rising incidence of these tumors has prompted a rigorous investigation of the etiology, diagnosis and management of ITGCN. Bilateral testicular cancer is closely linked with ITGCN, as patients with unilateral testicular cancer are at the highest risk for a future malignancy in the contralateral testicle. Methods : A literature review directed at ITGCN and bilateral testis cancer was performed using the Medline/PubMed database. Our review focused on the pathogenesis, risk factors, diagnosis and treatment regimens utilized. Results : Major advances have been made in the understanding of ITGCN over the past 30 years. There is evidence that TGCTs arise from ITGCN, ITGCN is closely related to fetal gonocytes, and that events in pre- and perinatal period may result in abnormal persistence of fetal gonocytes leading to ITGCN and subsequent TGCT. Controversy exists regarding the need to biopsy men at increased risk of TGCT, as well as the best approach to managing patients with known ITGCN. Bilateral testicular cancer has excellent outcomes in the current era of platinum-based chemotherapy. Conclusion : The optimal management of patients at risk for ITGCN and future TGCT is still a matter of debate. Individualization of management, including biopsy and treatment, should be based on risk factors for TGCT, compliance with potential surveillance, and patient preferences particularly with regard to fertility.

Original languageEnglish
Pages (from-to)64-71
Number of pages8
JournalIndian Journal of Urology
Volume26
Issue number1
DOIs
StatePublished - Jan 1 2010

Fingerprint

Germ Cell and Embryonal Neoplasms
Testicular Neoplasms
Testis
Germ Cells
Neoplasms
Biopsy
Patient Preference
Platinum
PubMed
Fertility
Testicular Germ Cell Tumor
Young Adult
Databases

Keywords

  • Bilateral testicular cancer
  • Intratubular germ cell neoplasia
  • Testicular germ cell tumor

ASJC Scopus subject areas

  • Urology

Cite this

Intratubular germ cell neoplasms of the testis and bilateral testicular tumors : Clinical significance and management options. / Risk, Michael C.; Masterson, Timothy.

In: Indian Journal of Urology, Vol. 26, No. 1, 01.01.2010, p. 64-71.

Research output: Contribution to journalArticle

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