Intravenous diazepam fails to change growth hormone and cortisol secretion in humans

Alan Breier, Dennis S. Charney, George R. Heninger

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Some, but not all studies have reported that a single dose of benzodiazepine affects growth hormone (GH) and cortisol secretion in healthy volunteers. The majority of studies that found GH elevations after benzodiazepine administration did not use placebo trials. The present placebo-controlled investigation determined plasma GH and cortisol levels after intravenous administration of diazepam (0.15 mg/kg) to 10 healthy volunteers. Neither GH nor cortisol secretion changed significantly after diazepam infusion. The lack of placebo trials and the presence of elevated baseline GH values may have been responsible for peak GH elevations reported in previous studies.

Original languageEnglish (US)
Pages (from-to)293-299
Number of pages7
JournalPsychiatry Research
Volume18
Issue number4
DOIs
StatePublished - Aug 1986

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Keywords

  • Growth hormone
  • cortisol
  • diazepam
  • healthy volunteers

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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