Intravenous GABA administration is anxiogenic in man

John I. Nurnberger, Wade H. Berrettini, Susan Simmons-Alling, Juliet J. Guroff, Elliot S. Gershon

Research output: Contribution to journalArticle

15 Scopus citations


Seven persons (three normal volunteers and four euthymic bipolar patients) received one to four doses of γ-aminobutyric acid (GABA) intravenously. All subjects reported dysphoria, and their mood disturbance scores on the Profile of Mood States were significantly increased in a dose-related fashion. Placebo infusions did not produce similar responses. Mood disturbance was accompanied by a dose-related increase in pulse and blood pressure.

Original languageEnglish (US)
Pages (from-to)113-117
Number of pages5
JournalPsychiatry Research
Issue number2
StatePublished - Oct 1986
Externally publishedYes


  • anxiety
  • γ-Aminobutyric acid

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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