Intravenous GABA administration is anxiogenic in man

John Nurnberger, Wade H. Berrettini, Susan Simmons-Alling, Juliet J. Guroff, Elliot S. Gershon

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Seven persons (three normal volunteers and four euthymic bipolar patients) received one to four doses of γ-aminobutyric acid (GABA) intravenously. All subjects reported dysphoria, and their mood disturbance scores on the Profile of Mood States were significantly increased in a dose-related fashion. Placebo infusions did not produce similar responses. Mood disturbance was accompanied by a dose-related increase in pulse and blood pressure.

Original languageEnglish (US)
Pages (from-to)113-117
Number of pages5
JournalPsychiatry Research
Volume19
Issue number2
DOIs
StatePublished - 1986
Externally publishedYes

Fingerprint

Intravenous Administration
gamma-Aminobutyric Acid
Blood Pressure
Aminobutyrates
Healthy Volunteers
Placebos

Keywords

  • anxiety
  • γ-Aminobutyric acid

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Nurnberger, J., Berrettini, W. H., Simmons-Alling, S., Guroff, J. J., & Gershon, E. S. (1986). Intravenous GABA administration is anxiogenic in man. Psychiatry Research, 19(2), 113-117. https://doi.org/10.1016/0165-1781(86)90004-1

Intravenous GABA administration is anxiogenic in man. / Nurnberger, John; Berrettini, Wade H.; Simmons-Alling, Susan; Guroff, Juliet J.; Gershon, Elliot S.

In: Psychiatry Research, Vol. 19, No. 2, 1986, p. 113-117.

Research output: Contribution to journalArticle

Nurnberger, J, Berrettini, WH, Simmons-Alling, S, Guroff, JJ & Gershon, ES 1986, 'Intravenous GABA administration is anxiogenic in man', Psychiatry Research, vol. 19, no. 2, pp. 113-117. https://doi.org/10.1016/0165-1781(86)90004-1
Nurnberger, John ; Berrettini, Wade H. ; Simmons-Alling, Susan ; Guroff, Juliet J. ; Gershon, Elliot S. / Intravenous GABA administration is anxiogenic in man. In: Psychiatry Research. 1986 ; Vol. 19, No. 2. pp. 113-117.
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