Intrinsic brain activity changes associated with adjuvant chemotherapy in older women with breast cancer: a pilot longitudinal study

Bihong T. Chen, Taihao Jin, Sunita K. Patel, Ningrong Ye, Huiyan Ma, Chi Wah Wong, Russell C. Rockne, James C. Root, Andrew Saykin, Tim A. Ahles, Andrei I. Holodny, Neal Prakash, Joanne Mortimer, James Waisman, Yuan Yuan, Daneng Li, Mina S. Sedrak, Jessica Vazquez, Vani Katheria, William Dale

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Abstract

Purpose: Older cancer patients are at increased risk of cancer-related cognitive impairment. The purpose of this study was to assess the alterations in intrinsic brain activity associated with adjuvant chemotherapy in older women with breast cancer. Methods: Chemotherapy treatment (CT) group included sixteen women aged ≥ 60 years (range 60–82 years) with stage I–III breast cancers, who underwent both resting-state functional magnetic resonance imaging (rs-fMRI) and neuropsychological testing with NIH Toolbox for Cognition before adjuvant chemotherapy, at time point 1 (TP1), and again within 1 month after completing chemotherapy, at time point 2 (TP2). Fourteen age- and sex-matched healthy controls (HC) underwent the same assessments at matched intervals. Three voxel-wise rs-fMRI parameters: amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), and regional homogeneity, were computed at each time point. The changes in rs-fMRI parameters from TP1 to TP2 for each group, the group differences in changes (the CT group vs. the HC group), and the group difference in the baseline rs-fMRI parameters were assessed. In addition, correlative analysis between the rs-fMRI parameters and neuropsychological testing scores was also performed. Results: In the CT group, one brain region, which included parts of the bilateral subcallosal gyri and right anterior cingulate gyrus, displayed increased ALFF from TP1 to TP2 (cluster p-corrected = 0.024); another brain region in the left precuneus displayed decreased fALFF from TP1 to TP2 (cluster level p-corrected = 0.025). No significant changes in the rs-fMRI parameters from TP1 to TP2 were observed in the HC group. Although ALFF and fALFF alterations were observed only in the CT group, none of the between-group differences in rs-fMRI parameter changes reached statistical significance. Conclusions: Our study results of ALFF and fALFF alterations in the chemotherapy-treated women suggest that adjuvant chemotherapy may affect intrinsic brain activity in older women with breast cancer.

Original languageEnglish (US)
JournalBreast Cancer Research and Treatment
DOIs
StatePublished - Jan 1 2019

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Adjuvant Chemotherapy
Longitudinal Studies
Breast Neoplasms
Brain
Magnetic Resonance Imaging
Drug Therapy
Control Groups
Parietal Lobe
Gyrus Cinguli
Therapeutics
Cognition
Neoplasms

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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Intrinsic brain activity changes associated with adjuvant chemotherapy in older women with breast cancer : a pilot longitudinal study. / Chen, Bihong T.; Jin, Taihao; Patel, Sunita K.; Ye, Ningrong; Ma, Huiyan; Wong, Chi Wah; Rockne, Russell C.; Root, James C.; Saykin, Andrew; Ahles, Tim A.; Holodny, Andrei I.; Prakash, Neal; Mortimer, Joanne; Waisman, James; Yuan, Yuan; Li, Daneng; Sedrak, Mina S.; Vazquez, Jessica; Katheria, Vani; Dale, William.

In: Breast Cancer Research and Treatment, 01.01.2019.

Research output: Contribution to journalArticle

Chen, BT, Jin, T, Patel, SK, Ye, N, Ma, H, Wong, CW, Rockne, RC, Root, JC, Saykin, A, Ahles, TA, Holodny, AI, Prakash, N, Mortimer, J, Waisman, J, Yuan, Y, Li, D, Sedrak, MS, Vazquez, J, Katheria, V & Dale, W 2019, 'Intrinsic brain activity changes associated with adjuvant chemotherapy in older women with breast cancer: a pilot longitudinal study', Breast Cancer Research and Treatment. https://doi.org/10.1007/s10549-019-05230-y
Chen, Bihong T. ; Jin, Taihao ; Patel, Sunita K. ; Ye, Ningrong ; Ma, Huiyan ; Wong, Chi Wah ; Rockne, Russell C. ; Root, James C. ; Saykin, Andrew ; Ahles, Tim A. ; Holodny, Andrei I. ; Prakash, Neal ; Mortimer, Joanne ; Waisman, James ; Yuan, Yuan ; Li, Daneng ; Sedrak, Mina S. ; Vazquez, Jessica ; Katheria, Vani ; Dale, William. / Intrinsic brain activity changes associated with adjuvant chemotherapy in older women with breast cancer : a pilot longitudinal study. In: Breast Cancer Research and Treatment. 2019.
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abstract = "Purpose: Older cancer patients are at increased risk of cancer-related cognitive impairment. The purpose of this study was to assess the alterations in intrinsic brain activity associated with adjuvant chemotherapy in older women with breast cancer. Methods: Chemotherapy treatment (CT) group included sixteen women aged ≥ 60 years (range 60–82 years) with stage I–III breast cancers, who underwent both resting-state functional magnetic resonance imaging (rs-fMRI) and neuropsychological testing with NIH Toolbox for Cognition before adjuvant chemotherapy, at time point 1 (TP1), and again within 1 month after completing chemotherapy, at time point 2 (TP2). Fourteen age- and sex-matched healthy controls (HC) underwent the same assessments at matched intervals. Three voxel-wise rs-fMRI parameters: amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), and regional homogeneity, were computed at each time point. The changes in rs-fMRI parameters from TP1 to TP2 for each group, the group differences in changes (the CT group vs. the HC group), and the group difference in the baseline rs-fMRI parameters were assessed. In addition, correlative analysis between the rs-fMRI parameters and neuropsychological testing scores was also performed. Results: In the CT group, one brain region, which included parts of the bilateral subcallosal gyri and right anterior cingulate gyrus, displayed increased ALFF from TP1 to TP2 (cluster p-corrected = 0.024); another brain region in the left precuneus displayed decreased fALFF from TP1 to TP2 (cluster level p-corrected = 0.025). No significant changes in the rs-fMRI parameters from TP1 to TP2 were observed in the HC group. Although ALFF and fALFF alterations were observed only in the CT group, none of the between-group differences in rs-fMRI parameter changes reached statistical significance. Conclusions: Our study results of ALFF and fALFF alterations in the chemotherapy-treated women suggest that adjuvant chemotherapy may affect intrinsic brain activity in older women with breast cancer.",
author = "Chen, {Bihong T.} and Taihao Jin and Patel, {Sunita K.} and Ningrong Ye and Huiyan Ma and Wong, {Chi Wah} and Rockne, {Russell C.} and Root, {James C.} and Andrew Saykin and Ahles, {Tim A.} and Holodny, {Andrei I.} and Neal Prakash and Joanne Mortimer and James Waisman and Yuan Yuan and Daneng Li and Sedrak, {Mina S.} and Jessica Vazquez and Vani Katheria and William Dale",
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T1 - Intrinsic brain activity changes associated with adjuvant chemotherapy in older women with breast cancer

T2 - a pilot longitudinal study

AU - Chen, Bihong T.

AU - Jin, Taihao

AU - Patel, Sunita K.

AU - Ye, Ningrong

AU - Ma, Huiyan

AU - Wong, Chi Wah

AU - Rockne, Russell C.

AU - Root, James C.

AU - Saykin, Andrew

AU - Ahles, Tim A.

AU - Holodny, Andrei I.

AU - Prakash, Neal

AU - Mortimer, Joanne

AU - Waisman, James

AU - Yuan, Yuan

AU - Li, Daneng

AU - Sedrak, Mina S.

AU - Vazquez, Jessica

AU - Katheria, Vani

AU - Dale, William

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Purpose: Older cancer patients are at increased risk of cancer-related cognitive impairment. The purpose of this study was to assess the alterations in intrinsic brain activity associated with adjuvant chemotherapy in older women with breast cancer. Methods: Chemotherapy treatment (CT) group included sixteen women aged ≥ 60 years (range 60–82 years) with stage I–III breast cancers, who underwent both resting-state functional magnetic resonance imaging (rs-fMRI) and neuropsychological testing with NIH Toolbox for Cognition before adjuvant chemotherapy, at time point 1 (TP1), and again within 1 month after completing chemotherapy, at time point 2 (TP2). Fourteen age- and sex-matched healthy controls (HC) underwent the same assessments at matched intervals. Three voxel-wise rs-fMRI parameters: amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), and regional homogeneity, were computed at each time point. The changes in rs-fMRI parameters from TP1 to TP2 for each group, the group differences in changes (the CT group vs. the HC group), and the group difference in the baseline rs-fMRI parameters were assessed. In addition, correlative analysis between the rs-fMRI parameters and neuropsychological testing scores was also performed. Results: In the CT group, one brain region, which included parts of the bilateral subcallosal gyri and right anterior cingulate gyrus, displayed increased ALFF from TP1 to TP2 (cluster p-corrected = 0.024); another brain region in the left precuneus displayed decreased fALFF from TP1 to TP2 (cluster level p-corrected = 0.025). No significant changes in the rs-fMRI parameters from TP1 to TP2 were observed in the HC group. Although ALFF and fALFF alterations were observed only in the CT group, none of the between-group differences in rs-fMRI parameter changes reached statistical significance. Conclusions: Our study results of ALFF and fALFF alterations in the chemotherapy-treated women suggest that adjuvant chemotherapy may affect intrinsic brain activity in older women with breast cancer.

AB - Purpose: Older cancer patients are at increased risk of cancer-related cognitive impairment. The purpose of this study was to assess the alterations in intrinsic brain activity associated with adjuvant chemotherapy in older women with breast cancer. Methods: Chemotherapy treatment (CT) group included sixteen women aged ≥ 60 years (range 60–82 years) with stage I–III breast cancers, who underwent both resting-state functional magnetic resonance imaging (rs-fMRI) and neuropsychological testing with NIH Toolbox for Cognition before adjuvant chemotherapy, at time point 1 (TP1), and again within 1 month after completing chemotherapy, at time point 2 (TP2). Fourteen age- and sex-matched healthy controls (HC) underwent the same assessments at matched intervals. Three voxel-wise rs-fMRI parameters: amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), and regional homogeneity, were computed at each time point. The changes in rs-fMRI parameters from TP1 to TP2 for each group, the group differences in changes (the CT group vs. the HC group), and the group difference in the baseline rs-fMRI parameters were assessed. In addition, correlative analysis between the rs-fMRI parameters and neuropsychological testing scores was also performed. Results: In the CT group, one brain region, which included parts of the bilateral subcallosal gyri and right anterior cingulate gyrus, displayed increased ALFF from TP1 to TP2 (cluster p-corrected = 0.024); another brain region in the left precuneus displayed decreased fALFF from TP1 to TP2 (cluster level p-corrected = 0.025). No significant changes in the rs-fMRI parameters from TP1 to TP2 were observed in the HC group. Although ALFF and fALFF alterations were observed only in the CT group, none of the between-group differences in rs-fMRI parameter changes reached statistical significance. Conclusions: Our study results of ALFF and fALFF alterations in the chemotherapy-treated women suggest that adjuvant chemotherapy may affect intrinsic brain activity in older women with breast cancer.

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