Intrinsic cardiac nerve activity and paroxysmal atrial tachyarrhythmia in ambulatory dogs

Eue Keun Choi, Mark J. Shen, Seongwook Han, Daehyeok Kim, Samuel Hwang, Sameh Sayfo, Gianfranco Piccirillo, Kyle Frick, Michael C. Fishbein, Chun Hwang, Shien Fong Lin, Peng Sheng Chen

Research output: Contribution to journalArticle

157 Scopus citations

Abstract

BACKGROUND-: Little is known about the relationship between intrinsic cardiac nerve activity (ICNA) and spontaneous arrhythmias in ambulatory animals. METHODS AND RESULTS-: We implanted radiotransmitters to record extrinsic cardiac nerve activity (ECNA; including stellate ganglion nerve activity and vagal nerve activity) and ICNA (including superior left ganglionated plexi nerve activity and ligament of Marshall nerve activity) in 6 ambulatory dogs. Intermittent rapid left atrial pacing was performed to induce paroxysmal atrial fibrillation or atrial tachycardia. The vast majority (94%) of ligament of Marshall nerve activity were preceded by or coactivated with ECNA (stellate ganglion nerve activity or vagal nerve activity), whereas 6% of episodes were activated alone without concomitant stellate ganglion nerve activity or vagal nerve activity. Paroxysmal atrial fibrillation and atrial tachycardia were invariably (100%) preceded (<5 seconds) by ICNA. Most paroxysmal atrial tachycardia events (89%) were preceded by ICNA and sympathovagal coactivation, whereas 11% were preceded by ICNA and stellate ganglion nerve activity-only activation. Most paroxysmal atrial fibrillation events were preceded only by ICNA (72%); the remaining 28% were preceded by ECNA and ICNA together. Complex fractionated atrial electrograms were observed during ICNA discharges that preceded the onset of paroxysmal atrial tachycardia and atrial fibrillation. Immunostaining confirmed the presence of both adrenergic and cholinergic nerve at ICNA sites. CONCLUSIONS-: There is a significant temporal relationship between ECNA and ICNA. However, ICNA can also activate alone. All paroxysmal atrial tachycardia and atrial fibrillation episodes were invariably preceded by ICNA. These findings suggest that ICNA (either alone or in collaboration with ECNA) is an invariable trigger of paroxysmal atrial tachyarrhythmias. ICNA might contaminate local atrial electrograms, resulting in complex fractionated atrial electrogram-like activity.

Original languageEnglish (US)
Pages (from-to)2615-2623
Number of pages9
JournalCirculation
Volume121
Issue number24
DOIs
StatePublished - Jun 22 2010

Keywords

  • atrial fibrillation
  • autonomic nervous system
  • physiology
  • tachyarrhythmia

ASJC Scopus subject areas

  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

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    Choi, E. K., Shen, M. J., Han, S., Kim, D., Hwang, S., Sayfo, S., Piccirillo, G., Frick, K., Fishbein, M. C., Hwang, C., Lin, S. F., & Chen, P. S. (2010). Intrinsic cardiac nerve activity and paroxysmal atrial tachyarrhythmia in ambulatory dogs. Circulation, 121(24), 2615-2623. https://doi.org/10.1161/CIRCULATIONAHA.109.919829