Intrinsic disorder and functional proteomics

Predrag Radivojac, Lilia M. Iakoucheva, Christopher J. Oldfield, Zoran Obradovic, Vladimir N. Uversky, A. Dunker

Research output: Contribution to journalArticle

500 Citations (Scopus)

Abstract

The recent advances in the prediction of intrinsically disordered proteins and the use of protein disorder prediction in the fields of molecular biology and bioinformatics are reviewed here, especially with regard to protein function. First, a close look is taken at intrinsically disordered proteins and then at the methods used for their experimental characterization. Next, the major statistical properties of disordered regions are summarized, and prediction models developed thus far are described, including their numerous applications in functional proteomics. The future of the prediction of protein disorder and the future uses of such predictions in functional proteomics comprise the last section of this article.

Original languageEnglish
Pages (from-to)1439-1456
Number of pages18
JournalBiophysical Journal
Volume92
Issue number5
DOIs
StatePublished - Mar 2007

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Intrinsically Disordered Proteins
Proteomics
Proteins
Computational Biology
Molecular Biology

ASJC Scopus subject areas

  • Biophysics

Cite this

Radivojac, P., Iakoucheva, L. M., Oldfield, C. J., Obradovic, Z., Uversky, V. N., & Dunker, A. (2007). Intrinsic disorder and functional proteomics. Biophysical Journal, 92(5), 1439-1456. https://doi.org/10.1529/biophysj.106.094045

Intrinsic disorder and functional proteomics. / Radivojac, Predrag; Iakoucheva, Lilia M.; Oldfield, Christopher J.; Obradovic, Zoran; Uversky, Vladimir N.; Dunker, A.

In: Biophysical Journal, Vol. 92, No. 5, 03.2007, p. 1439-1456.

Research output: Contribution to journalArticle

Radivojac, P, Iakoucheva, LM, Oldfield, CJ, Obradovic, Z, Uversky, VN & Dunker, A 2007, 'Intrinsic disorder and functional proteomics', Biophysical Journal, vol. 92, no. 5, pp. 1439-1456. https://doi.org/10.1529/biophysj.106.094045
Radivojac P, Iakoucheva LM, Oldfield CJ, Obradovic Z, Uversky VN, Dunker A. Intrinsic disorder and functional proteomics. Biophysical Journal. 2007 Mar;92(5):1439-1456. https://doi.org/10.1529/biophysj.106.094045
Radivojac, Predrag ; Iakoucheva, Lilia M. ; Oldfield, Christopher J. ; Obradovic, Zoran ; Uversky, Vladimir N. ; Dunker, A. / Intrinsic disorder and functional proteomics. In: Biophysical Journal. 2007 ; Vol. 92, No. 5. pp. 1439-1456.
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