Intrinsic disorder and functional proteomics

Predrag Radivojac, Lilia M. Iakoucheva, Christopher J. Oldfield, Zoran Obradovic, Vladimir N. Uversky, A. Keith Dunker

Research output: Contribution to journalArticle

514 Scopus citations

Abstract

The recent advances in the prediction of intrinsically disordered proteins and the use of protein disorder prediction in the fields of molecular biology and bioinformatics are reviewed here, especially with regard to protein function. First, a close look is taken at intrinsically disordered proteins and then at the methods used for their experimental characterization. Next, the major statistical properties of disordered regions are summarized, and prediction models developed thus far are described, including their numerous applications in functional proteomics. The future of the prediction of protein disorder and the future uses of such predictions in functional proteomics comprise the last section of this article.

Original languageEnglish (US)
Pages (from-to)1439-1456
Number of pages18
JournalBiophysical journal
Volume92
Issue number5
DOIs
StatePublished - Mar 2007

ASJC Scopus subject areas

  • Biophysics

Fingerprint Dive into the research topics of 'Intrinsic disorder and functional proteomics'. Together they form a unique fingerprint.

  • Cite this

    Radivojac, P., Iakoucheva, L. M., Oldfield, C. J., Obradovic, Z., Uversky, V. N., & Dunker, A. K. (2007). Intrinsic disorder and functional proteomics. Biophysical journal, 92(5), 1439-1456. https://doi.org/10.1529/biophysj.106.094045