Intrinsic disorder and prote in modifications

Building an SVM predictor for methylation

Kenneth M. Daily, Predrag Radivojac, A. Dunker

Research output: Chapter in Book/Report/Conference proceedingConference contribution

35 Citations (Scopus)

Abstract

Post-translational prote in modifications play an important role in many protein path ways and interactions. It has been hypothesized that modifications to prote insoccur in regions that are easily accessible, and many have been determined to belocated with in intrinsically disordered regions. However, identifying precise locations of prote in modifications involve sex pensive and time consuming laboratory work. Thus, automated identification of these sites is helpful. This paper studies methylated proteins and describes methods of building a predictor for arginine and lysine methylation sites using support vector machines. Our results indicate that, based on current data, both arginine and lysine methylation sites are likely to be intrinsically disordered and that the accuracies of methylation site predictions are high enough to be useful for prote in screening and for testing biological hypotheses.

Original languageEnglish
Title of host publicationProceedings of the 2005 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB '05
Volume2005
StatePublished - 2005
Event2005 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB '05 - La Jolla, CA, United States
Duration: Nov 14 2005Nov 15 2005

Other

Other2005 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB '05
CountryUnited States
CityLa Jolla, CA
Period11/14/0511/15/05

Fingerprint

Methylation
Arginine
Proteins
Support vector machines
Screening
Testing

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Daily, K. M., Radivojac, P., & Dunker, A. (2005). Intrinsic disorder and prote in modifications: Building an SVM predictor for methylation. In Proceedings of the 2005 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB '05 (Vol. 2005). [1594957]

Intrinsic disorder and prote in modifications : Building an SVM predictor for methylation. / Daily, Kenneth M.; Radivojac, Predrag; Dunker, A.

Proceedings of the 2005 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB '05. Vol. 2005 2005. 1594957.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Daily, KM, Radivojac, P & Dunker, A 2005, Intrinsic disorder and prote in modifications: Building an SVM predictor for methylation. in Proceedings of the 2005 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB '05. vol. 2005, 1594957, 2005 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB '05, La Jolla, CA, United States, 11/14/05.
Daily KM, Radivojac P, Dunker A. Intrinsic disorder and prote in modifications: Building an SVM predictor for methylation. In Proceedings of the 2005 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB '05. Vol. 2005. 2005. 1594957
Daily, Kenneth M. ; Radivojac, Predrag ; Dunker, A. / Intrinsic disorder and prote in modifications : Building an SVM predictor for methylation. Proceedings of the 2005 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB '05. Vol. 2005 2005.
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