Introduction and Overview of DNA Repair Targets: From Bench to Clinic

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

This chapter provides an overview of DNA repair targets. The critical role of DNA repair in preventing cancer in humans first came to light in studying individuals with xeroderma pigmentosum (XP), a rare recessive genetic disorder characterized by the inability to repair DNA damage caused by ultraviolet light. This deficiency leads to premature aging and multiple forms of skin cancer. DNA repair in its strictest sense means biological processes during which alterations in the chemistry of DNA are removed and the integrity of the genome is restored. DNA is the only biologic molecule that relies solely on its "survival" and the integrity of its information by repairing existing molecules instead of synthesizing new ones. It accumulates damage from both endogenous and exogenous sources over its lifetime.

Original languageEnglish
Pages (from-to)1-16
Number of pages16
JournalUnknown Journal
DOIs
StatePublished - 2012

ASJC Scopus subject areas

  • Dentistry(all)
  • Medicine(all)

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