Inverted papilloma of the urinary bladder: A molecular genetic appraisal

Ming Tse Sung, John N. Eble, Mingsheng Wang, Puay Hoon Tan, Antonio Lopez-Beltran, Liang Cheng

Research output: Contribution to journalArticle

44 Scopus citations


Inverted papilloma of urinary bladder is an uncommon urothelial neoplasm. Its relationship to urothelial carcinoma is controversial. Little is known of the genetic abnormalities of inverted papilloma. To better understand its genetics, we analyzed 39 inverted papillomas, including 36 from men and three from women, for loss of heterozygosity (LOH). We examined four polymorphic microsatellite markers located on chromosome 9q32-33(D9S177), chromosome 9p22 (IFNA), chromosome 3p14.2 (D3S1300) and chromosome 17p13.1 (TP53), where genetic alterations occur frequently in urothelial carcinomas. Additionally, the status of inactivation of X-chromosome was examined in three female patients. The frequency of LOH in informative cases was 8% (3 of 37) for D9S177, 10% (4 of 38) for TP53, 8% (3 of 37) for IFNA and 8% (3 of 36) for D3S1300. In the analysis of X-chromosome inactivation, all three cases yielded informative results and one had nonrandom inactivation of X-chromosomes. The monoclonal origin demonstrated in the study of X-chromosome inactivation indicates the clonal process of inverted papilloma; however, the low incidence of LOH supports the view that inverted papilloma in urinary bladder is a benign neoplasm with molecular genetic abnormalities different from those of urothelial carcinoma.

Original languageEnglish (US)
Pages (from-to)1289-1294
Number of pages6
JournalModern Pathology
Issue number10
StatePublished - Oct 21 2006


  • Clonality
  • Inverted papilloma
  • Loss of heterogosity
  • Neoplasia
  • Urinary bladder
  • X-chromosome inactivation

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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