Investigation of [67Ga]dimethylgallium(III) acetylacetonate as a potential radiopharmaceutical

Deanna K. Coggin, Carla J. Mathias, Mark Green

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Carrier-added [67Ga]dimethylgallium(III) acetylacetonate, a four coordinate Ga complex with two hydrolytically-stable GaC bonds, was prepared at a specific activity of 2.8 mCi/mmol. The biodistribution of this tracer was determined following intravenous injection into rats as a 5% ethanol: 19% propylene glycol solution in saline. Although the myocardial levels of 67Ga were fairly constant over a 2 h time period (%ID/heart = 0.80 ± 0.19, 0.67 ± 0.04 and 0.62 ± 0.07 at 1, 30 and 120 min post-injection, respectively), somewhat slow clearance of activity from the blood would preclude the use of this organometallic gallium complex as a myocardial imaging agent.

Original languageEnglish (US)
Pages (from-to)283-285
Number of pages3
JournalNuclear Medicine and Biology
Volume21
Issue number2
DOIs
StatePublished - 1994
Externally publishedYes

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Propylene Glycol
Gallium
Radiopharmaceuticals
Sodium Chloride
Intravenous Injections
Ethanol
Injections
acetyl acetonate

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Investigation of [67Ga]dimethylgallium(III) acetylacetonate as a potential radiopharmaceutical. / Coggin, Deanna K.; Mathias, Carla J.; Green, Mark.

In: Nuclear Medicine and Biology, Vol. 21, No. 2, 1994, p. 283-285.

Research output: Contribution to journalArticle

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