Investigation of [67Ga]dimethylgallium(III) acetylacetonate as a potential radiopharmaceutical

Deanna K. Coggin, Carla J. Mathias, Mark A. Green

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Abstract

Carrier-added [67Ga]dimethylgallium(III) acetylacetonate, a four coordinate Ga complex with two hydrolytically-stable GaC bonds, was prepared at a specific activity of 2.8 mCi/mmol. The biodistribution of this tracer was determined following intravenous injection into rats as a 5% ethanol: 19% propylene glycol solution in saline. Although the myocardial levels of 67Ga were fairly constant over a 2 h time period (%ID/heart = 0.80 ± 0.19, 0.67 ± 0.04 and 0.62 ± 0.07 at 1, 30 and 120 min post-injection, respectively), somewhat slow clearance of activity from the blood would preclude the use of this organometallic gallium complex as a myocardial imaging agent.

Original languageEnglish (US)
Pages (from-to)283-285
Number of pages3
JournalNuclear Medicine and Biology
Volume21
Issue number2
DOIs
StatePublished - Feb 1994

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ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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