Investigation of the efficacy of micafungin in the treatment of histoplasmosis using two North American strains of Histoplasma capsulatum

Chadi A. Hage, Patricia Connolly, Daniel Horan, Michelle Durkin, Melinda Smedema, Robert Zarnowski, Patricia Smith, L. Joseph Wheat

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Micafungin alone and combined with liposomal amphotericin B was evaluated against two strains of Histoplasma capsulatum. Micafungin was active in vitro against the mold but not the yeast form but was ineffective in vivo. Micafungin appears to be ineffective in treatment of histoplasmosis.

Original languageEnglish (US)
Pages (from-to)4447-4450
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume55
Issue number9
DOIs
StatePublished - Sep 1 2011

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Histoplasma
Histoplasmosis
Fungi
Yeasts
micafungin

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Investigation of the efficacy of micafungin in the treatment of histoplasmosis using two North American strains of Histoplasma capsulatum. / Hage, Chadi A.; Connolly, Patricia; Horan, Daniel; Durkin, Michelle; Smedema, Melinda; Zarnowski, Robert; Smith, Patricia; Wheat, L. Joseph.

In: Antimicrobial Agents and Chemotherapy, Vol. 55, No. 9, 01.09.2011, p. 4447-4450.

Research output: Contribution to journalArticle

Hage, Chadi A. ; Connolly, Patricia ; Horan, Daniel ; Durkin, Michelle ; Smedema, Melinda ; Zarnowski, Robert ; Smith, Patricia ; Wheat, L. Joseph. / Investigation of the efficacy of micafungin in the treatment of histoplasmosis using two North American strains of Histoplasma capsulatum. In: Antimicrobial Agents and Chemotherapy. 2011 ; Vol. 55, No. 9. pp. 4447-4450.
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