Investigation of the Tissue Effects of a New Device for Intracorporeal Lithotripsy-the Swiss Lithoclast

J. D. Denstedt, H. A. Razvi, E. Rowe, David Grignon, P. M. Eberwein

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Currently three modalities are available for intracorporeal stone fragmentation-electrohydraulic, ultrasound and laser lithotripsy. A new device, the Swiss Lithoclast, has been developed by the Departments of Medical Electronics and Urology at the University of Lausanne, Switzerland. This device has been used clinically in several countries for the treatment of stones throughout the human urinary tract. While no adverse outcomes have been reported, the potential tissue effects of the device have not been thoroughly investigated in an animal model. The objective of the present study is to evaluate the possible acute and long-term tissue effects of this instrument on the pig urinary tract. In all acute animals, visible mucosal lesions were seen at the site of probe firing in the bladders and ureters. Histologic examination demonstrated the effects of acute trauma with edema, hemorrhage and mucosal denudation. No significant long-term tissue effects were noted either pathologically or on radiographs in the 3- and 6-week animals. This study confirms our clinical impression that the Swiss Lithoclast effectively fragments urinary calculi and is associated with a large margin of safety.

Original languageEnglish (US)
Pages (from-to)535-537
Number of pages3
JournalJournal of Urology
Volume153
Issue number2
DOIs
StatePublished - 1995
Externally publishedYes

Fingerprint

Lithotripsy
Urinary Tract
Equipment and Supplies
Laser Lithotripsy
Medical Electronics
Urinary Calculi
Urology
Ureter
Switzerland
Edema
Urinary Bladder
Swine
Animal Models
Hemorrhage
Safety
Wounds and Injuries
Therapeutics

ASJC Scopus subject areas

  • Urology

Cite this

Investigation of the Tissue Effects of a New Device for Intracorporeal Lithotripsy-the Swiss Lithoclast. / Denstedt, J. D.; Razvi, H. A.; Rowe, E.; Grignon, David; Eberwein, P. M.

In: Journal of Urology, Vol. 153, No. 2, 1995, p. 535-537.

Research output: Contribution to journalArticle

Denstedt, J. D. ; Razvi, H. A. ; Rowe, E. ; Grignon, David ; Eberwein, P. M. / Investigation of the Tissue Effects of a New Device for Intracorporeal Lithotripsy-the Swiss Lithoclast. In: Journal of Urology. 1995 ; Vol. 153, No. 2. pp. 535-537.
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