Investigation of TT virus in the etiology of pediatric acute lymphoblastic leukemia

Bruce Shiramizu, Qigui Yu, Nigjie Hu, Richard Yanagihara, Vivek R. Nerurkar

Research output: Contribution to journalArticle

21 Scopus citations


Infectious agents have been implicated in the pathogenesis of pediatric acute lymphoblastic leukemia (ALL). A novel human DNA virus, TT virus (TTV), has been identified in children possessing characteristics as an etiologic agent, making the virus a potential candidate. Analysis of specimens from children with ALL was performed to determine if an association exists. Archived specimens (79 peripheral blood mononuclear cells, PBMC/bone marrow cells, BMC, and 125 cerebrospinal fluid, CSF) obtained at diagnosis and during therapy from 28 pediatric patients were tested for TTV. All of the diagnostic BMC/PBMC were negative for TTV, but 7 patients had follow-up specimens that converted to TTV positivity. TTV was not detected in any CSF. The absence of TTV at diagnosis suggests TTV is unlikely to be causally associated with ALL in the cases analyzed. However, the data support TTV transmission through blood products and suggest that the CNS is not a sanctuary site for TTV.

Original languageEnglish (US)
Pages (from-to)543-551
Number of pages9
JournalPediatric Hematology and Oncology
Issue number8
StatePublished - Dec 1 2002


  • Acute lymphoblastic leukemia
  • Central nervous system
  • Circovirus
  • Polymerase chain reaction
  • TT virus

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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