Investigations on the antioxidant activity of 5,8-dihydroxy-1,4-dihydro-1, 4-methanonaphthalene (DDMN)

A. K. Mitra, V. B. Gawandi, K. George, H. Mohan, T. Mukherjee

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

5,8-dihydroxy-1,4-dihydro-1,4-methanonaphthalene (DDMN), a substituted phenol, is synthesized by the reduction of a cyclic dione, 1,4,4a,8a- tetrahydroendo1,4-methano-naphtha-5,8-dione (THMND). The pulse radiolysis technique has been employed to understand the nature of transient species formed by the reaction of radiolytic species of water radiolysis withDDMN. OHradicals were observed to react with DDMN with a bimolecular rate constant of 1.5 × 1010 dm3 mol-1 s-1. The inhibition of radiation-induced lipid-peroxidation by DDMN was studied in rat liver microsomes by assessing the formation of thiobarbituric acid reactive substances (TBARS). It was found to be strongly inhibitory. The results suggest that DDMN has very good antioxidant activity and may possibly emerge as a good radio-protector.

Original languageEnglish (US)
Pages (from-to)13-20
Number of pages8
JournalResearch on Chemical Intermediates
Volume35
Issue number1
DOIs
StatePublished - Jan 1 2009
Externally publishedYes

Keywords

  • 5,8-dihydroxy-1,4-dihydro-1,4-methanonaphthalene (DDMN)
  • Lipid peroxidation
  • Pulse radiolysis

ASJC Scopus subject areas

  • Chemistry(all)

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