Investigator ratings of ADHD symptoms during a randomized, placebo-controlled trial of atomoxetine: A comparison of parents and teachers as informants

Bradley N. Bohnstedt, William G. Kronenberger, David W. Dunn, Ann L. Giauque, Elisabeth A. Wood, Mary E. Rembusch, Deborah Lafata

Research output: Contribution to journalArticle

12 Scopus citations


This study compared investigator ratings of ADHD symptoms based on interviews with parents and teachers during a double-blind, placebo-controlled study of atomoxetine. Investigators completed the ADHD Rating Scale: Investigator (ADHDRS-I) based on separate semistructured interviews with the primary caretaker and teacher of the participant. Interviews were conducted at Visits 2 to 7 during a double-blind treatment protocol comparing atomoxetine (N = 10) and placebo (N = 6). Both parent- and teacher-based ratings were sensitive to change in ADHD symptoms with atomoxetine treatment. Parent-based assessment differentiated significantly between treatment with atomoxetine and placebo, whereas teacher-based assessment was less sensitive to change. Parents and teachers showed good agreement on change in ADHDRS-I scores. Investigator ratings based on parent- and teacher-report were sensitive to change in symptoms of ADHD during treatment with atomoxetine. Despite good agreement between parent- and teacher-based ratings of symptom change, parent-based ADHD symptom ratings are more sensitive to symptom change.

Original languageEnglish (US)
Pages (from-to)153-159
Number of pages7
JournalJournal of Attention Disorders
Issue number4
StatePublished - May 1 2005



  • ADHD
  • Assessment
  • Atomoxetine
  • Attention
  • Hyperactivity

ASJC Scopus subject areas

  • Psychology(all)

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