Invited review: Frontotemporal dementia caused by microtubule-associated protein tau gene (MAPT) mutations: A chameleon for neuropathology and neuroimaging

Bernardino Ghetti, Adrian L. Oblak, Bradley F. Boeve, Keith A. Johnson, Bradford C. Dickerson, Michel Goedert

Research output: Contribution to journalReview article

161 Scopus citations

Abstract

Hereditary frontotemporal dementia associated with mutations in the microtubule-associated protein tau gene (MAPT) is a protean disorder. Three neuropathologic subtypes can be recognized, based on the presence of inclusions made of tau isoforms with three and four repeats, predominantly three repeats and mostly four repeats. This is relevant for establishing a correlation between structural magnetic resonance imaging and positron emission tomography using tracers specific for aggregated tau. Longitudinal studies will be essential to determine the evolution of anatomical alterations from the asymptomatic stage to the various phases of disease following the onset of symptoms.

Original languageEnglish (US)
Pages (from-to)24-46
Number of pages23
JournalNeuropathology and Applied Neurobiology
Volume41
Issue number1
DOIs
StatePublished - Feb 1 2015

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Keywords

  • FTDP-17 MAPT
  • Neurofibrillary tangle
  • Pick body
  • Tau
  • Tau aggregation
  • [F18]-T807

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Neurology
  • Histology
  • Physiology (medical)

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