Ipsilateral subcortical atrophy associated with temporal lobectomy

Karen J. Shedlack, Eun Kyu Lee, Rodney A. Radtke, Allan H. Friedman, Barbara J. Crain, Orest Boyko, K. Ranga Rama Krishnan

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Stereologic methods for determining the volume of cerebral structures in vivo via magnetic resonance imaging have identified unilateral hippocampal atrophy among patients with complex partial epilepsy of temporal lobe origin. Metabolic imaging has also identified altered metabolism in temporal as well as extratemporal regions among these patients. As the temporal cortex and subcortical nuclei of the limbic system are reciprocally connected with striatal projection fields, we examined the putamen nuclei for evidence of associated extratemporal volume asymmetry in patients before and after temporal lobectomy. There was no evidence of preoperative putamen volume asymmetry, but a significant post-operative decrement in ipsilateral putamen volume was observed. The magnitude of postsurgical putamen volume asymmetry was correlated with the duration of time since resection. Progressive degeneration of extratemporal projections of the temporal lobe may occur in association with temporal lobectomy.

Original languageEnglish (US)
Pages (from-to)295-304
Number of pages10
JournalPsychiatry Research
Volume54
Issue number3
DOIs
StatePublished - 1994
Externally publishedYes

Fingerprint

Putamen
Atrophy
Temporal Lobe
Complex Partial Epilepsy
Corpus Striatum
Limbic System
Magnetic Resonance Imaging

Keywords

  • basal ganglia
  • epilepsy
  • Magnetic resonance imaging
  • putamen

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Shedlack, K. J., Lee, E. K., Radtke, R. A., Friedman, A. H., Crain, B. J., Boyko, O., & Rama Krishnan, K. R. (1994). Ipsilateral subcortical atrophy associated with temporal lobectomy. Psychiatry Research, 54(3), 295-304. https://doi.org/10.1016/0165-1781(94)90023-X

Ipsilateral subcortical atrophy associated with temporal lobectomy. / Shedlack, Karen J.; Lee, Eun Kyu; Radtke, Rodney A.; Friedman, Allan H.; Crain, Barbara J.; Boyko, Orest; Rama Krishnan, K. Ranga.

In: Psychiatry Research, Vol. 54, No. 3, 1994, p. 295-304.

Research output: Contribution to journalArticle

Shedlack, KJ, Lee, EK, Radtke, RA, Friedman, AH, Crain, BJ, Boyko, O & Rama Krishnan, KR 1994, 'Ipsilateral subcortical atrophy associated with temporal lobectomy', Psychiatry Research, vol. 54, no. 3, pp. 295-304. https://doi.org/10.1016/0165-1781(94)90023-X
Shedlack KJ, Lee EK, Radtke RA, Friedman AH, Crain BJ, Boyko O et al. Ipsilateral subcortical atrophy associated with temporal lobectomy. Psychiatry Research. 1994;54(3):295-304. https://doi.org/10.1016/0165-1781(94)90023-X
Shedlack, Karen J. ; Lee, Eun Kyu ; Radtke, Rodney A. ; Friedman, Allan H. ; Crain, Barbara J. ; Boyko, Orest ; Rama Krishnan, K. Ranga. / Ipsilateral subcortical atrophy associated with temporal lobectomy. In: Psychiatry Research. 1994 ; Vol. 54, No. 3. pp. 295-304.
@article{f720fa0a97a64c3abc7cbc9a12b376db,
title = "Ipsilateral subcortical atrophy associated with temporal lobectomy",
abstract = "Stereologic methods for determining the volume of cerebral structures in vivo via magnetic resonance imaging have identified unilateral hippocampal atrophy among patients with complex partial epilepsy of temporal lobe origin. Metabolic imaging has also identified altered metabolism in temporal as well as extratemporal regions among these patients. As the temporal cortex and subcortical nuclei of the limbic system are reciprocally connected with striatal projection fields, we examined the putamen nuclei for evidence of associated extratemporal volume asymmetry in patients before and after temporal lobectomy. There was no evidence of preoperative putamen volume asymmetry, but a significant post-operative decrement in ipsilateral putamen volume was observed. The magnitude of postsurgical putamen volume asymmetry was correlated with the duration of time since resection. Progressive degeneration of extratemporal projections of the temporal lobe may occur in association with temporal lobectomy.",
keywords = "basal ganglia, epilepsy, Magnetic resonance imaging, putamen",
author = "Shedlack, {Karen J.} and Lee, {Eun Kyu} and Radtke, {Rodney A.} and Friedman, {Allan H.} and Crain, {Barbara J.} and Orest Boyko and {Rama Krishnan}, {K. Ranga}",
year = "1994",
doi = "10.1016/0165-1781(94)90023-X",
language = "English (US)",
volume = "54",
pages = "295--304",
journal = "Psychiatry Research",
issn = "0165-1781",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - Ipsilateral subcortical atrophy associated with temporal lobectomy

AU - Shedlack, Karen J.

AU - Lee, Eun Kyu

AU - Radtke, Rodney A.

AU - Friedman, Allan H.

AU - Crain, Barbara J.

AU - Boyko, Orest

AU - Rama Krishnan, K. Ranga

PY - 1994

Y1 - 1994

N2 - Stereologic methods for determining the volume of cerebral structures in vivo via magnetic resonance imaging have identified unilateral hippocampal atrophy among patients with complex partial epilepsy of temporal lobe origin. Metabolic imaging has also identified altered metabolism in temporal as well as extratemporal regions among these patients. As the temporal cortex and subcortical nuclei of the limbic system are reciprocally connected with striatal projection fields, we examined the putamen nuclei for evidence of associated extratemporal volume asymmetry in patients before and after temporal lobectomy. There was no evidence of preoperative putamen volume asymmetry, but a significant post-operative decrement in ipsilateral putamen volume was observed. The magnitude of postsurgical putamen volume asymmetry was correlated with the duration of time since resection. Progressive degeneration of extratemporal projections of the temporal lobe may occur in association with temporal lobectomy.

AB - Stereologic methods for determining the volume of cerebral structures in vivo via magnetic resonance imaging have identified unilateral hippocampal atrophy among patients with complex partial epilepsy of temporal lobe origin. Metabolic imaging has also identified altered metabolism in temporal as well as extratemporal regions among these patients. As the temporal cortex and subcortical nuclei of the limbic system are reciprocally connected with striatal projection fields, we examined the putamen nuclei for evidence of associated extratemporal volume asymmetry in patients before and after temporal lobectomy. There was no evidence of preoperative putamen volume asymmetry, but a significant post-operative decrement in ipsilateral putamen volume was observed. The magnitude of postsurgical putamen volume asymmetry was correlated with the duration of time since resection. Progressive degeneration of extratemporal projections of the temporal lobe may occur in association with temporal lobectomy.

KW - basal ganglia

KW - epilepsy

KW - Magnetic resonance imaging

KW - putamen

UR - http://www.scopus.com/inward/record.url?scp=0028598892&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028598892&partnerID=8YFLogxK

U2 - 10.1016/0165-1781(94)90023-X

DO - 10.1016/0165-1781(94)90023-X

M3 - Article

VL - 54

SP - 295

EP - 304

JO - Psychiatry Research

JF - Psychiatry Research

SN - 0165-1781

IS - 3

ER -