Irreversible intrapulmonary vascular changes after pulmonary vein stenosis complicating catheter ablation for atrial fibrillation

Hui Min Yang, Chi K. Lai, Jignesh Patel, John Moore, Peng-Sheng Chen, Kalyanam Shivkumar, Michael C. Fishbein

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Background: Pulmonary vein stenosis is a recognized complication of catheter ablation of arrhythmias emanating from the pulmonary vein; however, there is little information on secondary effects of pulmonary vein stenosis on lung tissue. Methods and results: A 55-year-old man with a history of paroxysmal atrial fibrillation refractory to antiarrhythmic medication had radiofrequency ablation in April 2003 and July 2003. Although these procedures were successful in resolving the patient's arrhythmia, they were complicated by the development of pulmonary vein stenosis of all four veins and pulmonary hypertension requiring patch annuloplasty of the pulmonary veins in October 2003. The patient was referred to our center for pulmonary vein stent placement in December 2003, June 2004, and August 2004, each time for recurrent hemoptysis. Due to persistent hemoptysis over the next several months, the patient underwent left lower lung lobectomy in September 2005. Microscopic examination of the lung showed marked medial thickening and intimal hyperplasia of large and small pulmonary veins and arteries, as well as focal organizing thrombi in the small arteries. The lung tissue showed extensive hemosiderin deposition indicative of prior hemorrhage. Conclusion: Chronic pulmonary vein stenosis after radiofrequency ablation of atrial fibrillation results in irreversible venous and arterial morphologic changes throughout the lung, including areas both close to, and remote from, the site of catheter ablation. Because there are persistent pathological changes remote from the ablation site causing the pulmonary hypertension, stenting the site of ablation to reopen large pulmonary veins may not be effective in treating the pulmonary hypertension.

Original languageEnglish (US)
Pages (from-to)51-55
Number of pages5
JournalCardiovascular Pathology
Volume16
Issue number1
DOIs
StatePublished - Jan 2007
Externally publishedYes

Fingerprint

Catheter Ablation
Pulmonary Veins
Atrial Fibrillation
Blood Vessels
Lung
Pulmonary Hypertension
Hemoptysis
Cardiac Arrhythmias
Tunica Intima
Hemosiderin
Pulmonary Artery
Hyperplasia
Stents
Veins
Thrombosis
Arteries
Pulmonary Vein Stenosis
Hemorrhage

Keywords

  • Atrial fibrillation
  • Pulmonary circulation
  • Pulmonary hypertension
  • Pulmonary vein stenosis
  • Radiofrequency catheter ablation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pathology and Forensic Medicine

Cite this

Irreversible intrapulmonary vascular changes after pulmonary vein stenosis complicating catheter ablation for atrial fibrillation. / Yang, Hui Min; Lai, Chi K.; Patel, Jignesh; Moore, John; Chen, Peng-Sheng; Shivkumar, Kalyanam; Fishbein, Michael C.

In: Cardiovascular Pathology, Vol. 16, No. 1, 01.2007, p. 51-55.

Research output: Contribution to journalArticle

Yang, Hui Min ; Lai, Chi K. ; Patel, Jignesh ; Moore, John ; Chen, Peng-Sheng ; Shivkumar, Kalyanam ; Fishbein, Michael C. / Irreversible intrapulmonary vascular changes after pulmonary vein stenosis complicating catheter ablation for atrial fibrillation. In: Cardiovascular Pathology. 2007 ; Vol. 16, No. 1. pp. 51-55.
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