Is ethanol a pro-drug? Acetaldehyde contribution to brain ethanol effects

Etienne Quertemont, C. J.Peter Eriksson, Sergey M. Zimatkin, Pavel S. Pronko, Marco Diana, Milena Pisano, Zachary A. Rodd, Richard R. Bell, Roberta J. Ward

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

This article presents the proceedings of a symposium at the 2004 meeting of the International Society for Biomedical Research on Alcoholism, held in Mannheim, Germany. The symposium was organized by Etienne Quertemont and chaired by C. J. Peter Eriksson. The presentations were (1) Brain ethanol metabolism and its behavior consequences, by Sergey M. Zimatkin and P. S. Pronko; (2) Acetaldehyde increases dopaminergic neuronal activity: a possible mechanism for acetaldehyde reinforcing effects, by Marco Diana and Milena Pisano; (3) Contrasting the reinforcing actions of acetaldehyde and ethanol within the ventral tegmental area (VTA) of alcohol-preferring (P) rats, by Zachary A. Rodd and Richard R. Bell; (4) Molecular and biochemical changes associated with acetaldehyde toxicity, by Roberta J. Ward; and (5) Role of acetaldehyde in human alcoholism and alcohol abuse, by C. J. Peter Eriksson.

Original languageEnglish (US)
Pages (from-to)1514-1521
Number of pages8
JournalAlcoholism: Clinical and Experimental Research
Volume29
Issue number8
DOIs
StatePublished - Aug 1 2005

Keywords

  • Acetaldehyde
  • Brain
  • Catalase
  • Dopamine
  • Ethanol
  • Self-Administration

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

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    Quertemont, E., Eriksson, C. J. P., Zimatkin, S. M., Pronko, P. S., Diana, M., Pisano, M., Rodd, Z. A., Bell, R. R., & Ward, R. J. (2005). Is ethanol a pro-drug? Acetaldehyde contribution to brain ethanol effects. Alcoholism: Clinical and Experimental Research, 29(8), 1514-1521. https://doi.org/10.1097/01.alc.0000175015.51329.45