Is there a role for surgical resection in the treatment of early-stage pancreatic lymphoma?

Leonidas Koniaris, Keith D. Lillemoe, Charles J. Yeo, Ross A. Abrams, Joanne Colemann, Attila Nakeeb, Henry Pitt, John L. Cameron

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Background: Pancreatic lymphoma is a rare neoplasm. The role of surgical resection in curing this disease is poorly defined. Study Design: From March 1983 to July 1997, eight patients with stage I or II primary pancreatic lymphoma were identified and retrospectively reviewed. All patients received chemotherapy, five patients received radiotherapy, and three patients also underwent surgical resection. A review of the published pancreatic lymphoma experience in the English-language literature was also undertaken. Results: Three patients underwent pancreaticoduode-nectomy with successful resection of the lymphoma and are disease free at 64, 62, and 53 months followup. Five patients were treated with nonresectional therapy. Three are disease free at 128, 51, and 24 months. Two patients died of disease at 9 and 37 months. A review of the pancreatic lymphoma experience in the English-language literature identified 122 cases of pancreatic lymphoma. Fifty-eight of these cases represented stage I or II lymphoma, which was treated without surgical resection with a 46% cure rate. Fifteen patients who had surgical resection for localized disease have been reported with a 94% cure rate. Conclusions: Based on both our single institution experience and the literature, it is suggested that surgical resection may play a beneficial role in the treatment of localized pancreatic lymphoma, although selection factors cannot be absolutely excluded. (C) 2000 by the American College of Surgeons.

Original languageEnglish (US)
Pages (from-to)319-330
Number of pages12
JournalJournal of the American College of Surgeons
Volume190
Issue number3
DOIs
StatePublished - Mar 2000
Externally publishedYes

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Lymphoma
Therapeutics
Language
Radiotherapy
Drug Therapy
Neoplasms

ASJC Scopus subject areas

  • Surgery

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Is there a role for surgical resection in the treatment of early-stage pancreatic lymphoma? / Koniaris, Leonidas; Lillemoe, Keith D.; Yeo, Charles J.; Abrams, Ross A.; Colemann, Joanne; Nakeeb, Attila; Pitt, Henry; Cameron, John L.

In: Journal of the American College of Surgeons, Vol. 190, No. 3, 03.2000, p. 319-330.

Research output: Contribution to journalArticle

Koniaris, Leonidas ; Lillemoe, Keith D. ; Yeo, Charles J. ; Abrams, Ross A. ; Colemann, Joanne ; Nakeeb, Attila ; Pitt, Henry ; Cameron, John L. / Is there a role for surgical resection in the treatment of early-stage pancreatic lymphoma?. In: Journal of the American College of Surgeons. 2000 ; Vol. 190, No. 3. pp. 319-330.
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