Ischemia-induced tight junction dysfunction in the kidney

James A. Marrs, Bruce A. Molitoris

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

The primary functions of the kidney, maintaining body volume and electrolyte balance, while removing nitrogenous and other waste products from the blood, are dependent upon size-selective filtration across the glomerulus and specific reabsorption of water, ions, and macromolecules by tubular epithelial cells. Regulation of these interrelated processes at the cellular level requires structural and biochemical polarization of the surface membrane of participating epithelial cells. For example, with normal renal function, approximately 150 liters of glomerular filtrate are produced every 24 h. About 99% of this volume is reabsorbed, and between 70 and 80% of this reabsorption occurs across proximal tubule cells. Therefore, small changes in reabsorptive characteristics across these cells can have profound effects on organ function.

Original languageEnglish (US)
Title of host publicationTight Junctions
PublisherCRC Press
Pages533-552
Number of pages20
ISBN (Electronic)9781420038538
ISBN (Print)9780849323836
DOIs
StatePublished - Jan 1 2001

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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