Isolated seizures in rats do not cause neuronal injury

M. T. Acosta, J. Munashinge, L. Zhang, Daniel A. Guerron, Alexander Vortmeyer, W. H. Theodore

Research output: Contribution to journalArticle

2 Scopus citations


Background- Previous studies have shown that status epilepticus can lead to neuronal injury. However, the effect of a small number of isolated seizures is uncertain. Methods- We used structural MRI and neuropathology to study the effects of isolated seizures induced by kainic acid (KA), (RS)-2-amino-3-(3-hydroxy-5-tert-butylisoxazole-4-yl)propanoic acid (ATPA), and α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate in rats. A group of animals received normal saline. After seizure induction, animals were followed for 12weeks. Results- ATPA and KA led to small but significant increases in ADC. There were no changes in T2 signal intensity or hippocampal volume. Blinded pathological examination showed no differences between animals receiving saline or glutamatergic agents. Conclusion- Our study suggests that isolated seizures cause minimal neuronal injury in rats. Published 2011. This article is a US Government work and is in the public domain in the USA.

Original languageEnglish (US)
Pages (from-to)30-37
Number of pages8
JournalActa Neurologica Scandinavica
Issue number1
StatePublished - Jan 1 2012
Externally publishedYes


  • Epilepsy
  • Neuroimaging
  • Seizures

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Acosta, M. T., Munashinge, J., Zhang, L., Guerron, D. A., Vortmeyer, A., & Theodore, W. H. (2012). Isolated seizures in rats do not cause neuronal injury. Acta Neurologica Scandinavica, 125(1), 30-37.