Isolated seminal vesicle invasion imparts better outcomes after radical retropubic prostatectomy for clinically localized prostate cancer

Prognostic stratification of pt3b disease by nodal and margin status

Timothy Masterson, Joseph A. Pettus, Richard G. Middleton, Robert A. Stephenson

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Objectives. To examine the survival differences in men with seminal vesicle invasion (SVI) according to surgical margin (SM) and nodal (N) status to characterize the influence of isolated SVI on disease progression after radical retropubic prostatectomy for clinically localized prostate cancer. Methods. We reviewed the records of 941 men who underwent radical retropubic prostatectomy for clinically localized prostate cancer between 1984 and 2002. Three groups with evidence of SVI (SM-/N-, SM+/N-, and N+) were analyzed to identify differences in age, preoperative prostate-specific antigen (PSA) level, biopsy Gleason score, surgical Gleason score, time to PSA progression, follow-up time, and cancer-specific and overall survival. Kaplan-Meier estimates and univariate and multivariate calculations were generated to examine differences in biochemical-free survival. Results. Of 941 patients, 87 were identified with SVI; of these, 28 (32.2%) were SM-/N-, 35 (40.2%) were SM+/N-, and 24 (27.6%) were N+. The median follow-up for all patients was 70 months. The 5-year biochemical progression-free rate for SM-/N-, SM+/N-, and N+ patients was 71.9%, 36.6%, and 25.9%, respectively. The median time to PSA progression for SM-/N-, SM+/N-, and N+ patients was 26, 16, and 6 months, respectively. The clinical stage, pretreatment PSA level, and margin and node status were statistically predictive (P

Original languageEnglish (US)
Pages (from-to)152-155
Number of pages4
JournalUrology
Volume66
Issue number1
DOIs
StatePublished - Jul 2005
Externally publishedYes

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Seminal Vesicles
Prostatectomy
Prostatic Neoplasms
Prostate-Specific Antigen
Neoplasm Grading
Survival
Margins of Excision
Kaplan-Meier Estimate
Disease Progression
Biopsy

ASJC Scopus subject areas

  • Urology

Cite this

Isolated seminal vesicle invasion imparts better outcomes after radical retropubic prostatectomy for clinically localized prostate cancer : Prognostic stratification of pt3b disease by nodal and margin status. / Masterson, Timothy; Pettus, Joseph A.; Middleton, Richard G.; Stephenson, Robert A.

In: Urology, Vol. 66, No. 1, 07.2005, p. 152-155.

Research output: Contribution to journalArticle

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abstract = "Objectives. To examine the survival differences in men with seminal vesicle invasion (SVI) according to surgical margin (SM) and nodal (N) status to characterize the influence of isolated SVI on disease progression after radical retropubic prostatectomy for clinically localized prostate cancer. Methods. We reviewed the records of 941 men who underwent radical retropubic prostatectomy for clinically localized prostate cancer between 1984 and 2002. Three groups with evidence of SVI (SM-/N-, SM+/N-, and N+) were analyzed to identify differences in age, preoperative prostate-specific antigen (PSA) level, biopsy Gleason score, surgical Gleason score, time to PSA progression, follow-up time, and cancer-specific and overall survival. Kaplan-Meier estimates and univariate and multivariate calculations were generated to examine differences in biochemical-free survival. Results. Of 941 patients, 87 were identified with SVI; of these, 28 (32.2{\%}) were SM-/N-, 35 (40.2{\%}) were SM+/N-, and 24 (27.6{\%}) were N+. The median follow-up for all patients was 70 months. The 5-year biochemical progression-free rate for SM-/N-, SM+/N-, and N+ patients was 71.9{\%}, 36.6{\%}, and 25.9{\%}, respectively. The median time to PSA progression for SM-/N-, SM+/N-, and N+ patients was 26, 16, and 6 months, respectively. The clinical stage, pretreatment PSA level, and margin and node status were statistically predictive (P",
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