Isolated trisomy of chromosomes 8, 11, 13 and 21 is an adverse prognostic factor in adults with de novo acute myeloid leukemia

results from Cancer and Leukemia Group B 8461.

Sherif Farag, Kellie J. Archer, Krzysztof Mrózek, James W. Vardiman, Andrew J. Carroll, Mark J. Pettenati, Joseph O. Moore, Jonathan E. Kolitz, Robert J. Mayer, Richard M. Stone, Richard A. Larson, Clara D. Bloomfield

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Isolated trisomy is a relatively common cytogenetic abnormality in acute myeloid leukemia (AML), but with uncertain prognostic significance. We studied a large cohort of newly diagnosed de novo AML patients karyotyped on CALGB 8461 from 1984-1999, where trisomy was the sole abnormality. The common isolated trisomies (IT(C)), +8, +11, +13 and +21, comprised 90% of all sole trisomies. The outcome of 101 IT(C) patients was compared to that of 976 with normal and "poor risk" cytogenetics. The overall survival (OS) for IT(C) patients was unsatisfactory with 10% [95% confidence interval (CI), 3-17%] alive at 5 years. Repeated cycles of I/HDAC intensification did not improve outcome. However, SCT significantly improved relapse-free survival (RFS). Among IT(C) patients

Original languageEnglish (US)
Pages (from-to)1041-1051
Number of pages11
JournalInternational Journal of Oncology
Volume21
Issue number5
StatePublished - Nov 2002
Externally publishedYes

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Chromosomes, Human, Pair 21
Chromosomes, Human, Pair 11
Trisomy
Acute Myeloid Leukemia
Leukemia
Neoplasms
Survival
Cytogenetics
Chromosome Aberrations
Confidence Intervals
Recurrence
Trisomy Chromosome 8

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Isolated trisomy of chromosomes 8, 11, 13 and 21 is an adverse prognostic factor in adults with de novo acute myeloid leukemia : results from Cancer and Leukemia Group B 8461. / Farag, Sherif; Archer, Kellie J.; Mrózek, Krzysztof; Vardiman, James W.; Carroll, Andrew J.; Pettenati, Mark J.; Moore, Joseph O.; Kolitz, Jonathan E.; Mayer, Robert J.; Stone, Richard M.; Larson, Richard A.; Bloomfield, Clara D.

In: International Journal of Oncology, Vol. 21, No. 5, 11.2002, p. 1041-1051.

Research output: Contribution to journalArticle

Farag, S, Archer, KJ, Mrózek, K, Vardiman, JW, Carroll, AJ, Pettenati, MJ, Moore, JO, Kolitz, JE, Mayer, RJ, Stone, RM, Larson, RA & Bloomfield, CD 2002, 'Isolated trisomy of chromosomes 8, 11, 13 and 21 is an adverse prognostic factor in adults with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B 8461.', International Journal of Oncology, vol. 21, no. 5, pp. 1041-1051.
Farag, Sherif ; Archer, Kellie J. ; Mrózek, Krzysztof ; Vardiman, James W. ; Carroll, Andrew J. ; Pettenati, Mark J. ; Moore, Joseph O. ; Kolitz, Jonathan E. ; Mayer, Robert J. ; Stone, Richard M. ; Larson, Richard A. ; Bloomfield, Clara D. / Isolated trisomy of chromosomes 8, 11, 13 and 21 is an adverse prognostic factor in adults with de novo acute myeloid leukemia : results from Cancer and Leukemia Group B 8461. In: International Journal of Oncology. 2002 ; Vol. 21, No. 5. pp. 1041-1051.
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abstract = "Isolated trisomy is a relatively common cytogenetic abnormality in acute myeloid leukemia (AML), but with uncertain prognostic significance. We studied a large cohort of newly diagnosed de novo AML patients karyotyped on CALGB 8461 from 1984-1999, where trisomy was the sole abnormality. The common isolated trisomies (IT(C)), +8, +11, +13 and +21, comprised 90{\%} of all sole trisomies. The outcome of 101 IT(C) patients was compared to that of 976 with normal and {"}poor risk{"} cytogenetics. The overall survival (OS) for IT(C) patients was unsatisfactory with 10{\%} [95{\%} confidence interval (CI), 3-17{\%}] alive at 5 years. Repeated cycles of I/HDAC intensification did not improve outcome. However, SCT significantly improved relapse-free survival (RFS). Among IT(C) patients",
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