Isolation and characterization of six new genome types of human adenovirus types 1 and 2

K. H. Fife, R. Ashley, L. Corey

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Several of the 41 types of human adenovirus have been divided into genome types based on aberrant restriction endonuclease digestion patterns of viral DNA. In the process of screening a large number of clinical adenovirus isolates by restriction endonuclease digestion of viral DNA, we have identified nine isolates from eight patients which were identified by neutralization as adenovirus type 1 or 2 but had aberrant cleavage patterns. Cleavage sites for the enzymes SmaI, EcoRI, HindIII, KpnI, and HpaI were mapped. The variants could be placed in six distinct groups based on cleavage patterns. The designation genome types 1a, 1b, 1c, 2b, 2c, and 2d are proposed for these isolates.

Original languageEnglish (US)
Pages (from-to)20-23
Number of pages4
JournalJournal of clinical microbiology
Volume21
Issue number1
DOIs
StatePublished - 1985

ASJC Scopus subject areas

  • Microbiology (medical)

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