Isolation of ALP, a novel divergent murine CC chemokine with a unique carboxy terminal extension

Robert Hromas, Hal E. Broxmeyer, Chang Kim, Kent Christopherson, Yong Hao Hou

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Chemokines are a family of related proteins that regulate leukocyte infiltration into inflamed tissue and play important roles in many disease processes. Chemokines are divided into two major groups, CC or CXC, based on their sequence around the amino terminal cysteines. We report here, the isolation of a novel murine CC chemokine termed ALP for its amino terminal peptide sequence. This novel chemokine is distantly related to other CC chemokines (37% identity with murine Exodus-1/LARC/Mip-3α), but has a unique carboxy terminal extension. It is expressed preferentially in testis, heart, and liver, which is atypical for CC chemokines.

Original languageEnglish (US)
Pages (from-to)737-740
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume258
Issue number3
DOIs
StatePublished - May 19 1999

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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