Isolation-rearing of rats produces deficits as adults in the serotonergic innervation of hippocampus

P. Whitaker-Azmitia, Feng Zhou, J. Hobin, A. Borella

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Isolation-rearing of rats causes a variety of behavioral changes, including anxiety, learning deficits and sensory changes related to schizophrenia. Similar changes are seen following loss of serotonin during development. Thus, the effects of isolation-rearing on behavior may be due to changes in serotonin. Sprague-Dawley rats were raised in groups of four (social animals) or in isolation, from postnatal day 22 until postnatal day 64. The hippocampi were examined immunochemically for changes in serotonin. Our findings show that serotonin terminals are lost throughout the CA regions of hippocampus, where there is also an associated loss of dendrites, but not in the molecular layer of the dentate gyrus. Thus, some of the brain and behavioral changes seen in isolation-reared animals could be due to loss of serotonin. (C) 2000 Published by Elsevier Science Inc.

Original languageEnglish
Pages (from-to)1755-1759
Number of pages5
JournalPeptides
Volume21
Issue number11
DOIs
StatePublished - 2000

Fingerprint

Rats
Hippocampus
Serotonin
Animals
Dentate Gyrus
Dendrites
Sprague Dawley Rats
Brain
Schizophrenia
Anxiety
Learning

Keywords

  • Hippocampus
  • MAP-2
  • Schizophrenia

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

Isolation-rearing of rats produces deficits as adults in the serotonergic innervation of hippocampus. / Whitaker-Azmitia, P.; Zhou, Feng; Hobin, J.; Borella, A.

In: Peptides, Vol. 21, No. 11, 2000, p. 1755-1759.

Research output: Contribution to journalArticle

Whitaker-Azmitia, P. ; Zhou, Feng ; Hobin, J. ; Borella, A. / Isolation-rearing of rats produces deficits as adults in the serotonergic innervation of hippocampus. In: Peptides. 2000 ; Vol. 21, No. 11. pp. 1755-1759.
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