Issues and trends in pediatric growth hormone therapy - An update from the GHMonitorSM observational registry

Pisit Pitukcheewanont, Paul Desrosiers, Joel Steelman, Robert Rapaport, John S. Fuqua, Nerissa C. Kreher, Anthony Hamlett

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

The GHMonitorSM observational registry collates data on pediatric subjects receiving Saizen® (recombinant human growth hormone (GH)) therapy. From January 2003 through August 2006, 1335 subjects were enrolled in the registry, approximately two-thirds of whom are male. The most common diagnosis in the registry is idiopathic growth hormone deficiency (58%). Most subjects in GHMonitorSM are receiving Saizen® doses using a needle-free delivery device, the cool.click® (73%). Mean height standard deviation scores show an improvement from -2.1 at screening to -1.1 following 3 years of Saizen® therapy. To date, adverse events have been reported in 4% of subjects. Three serious adverse events were identified to be related to Saizen® by the primary investigator: cellulitis at the injection site, behavioral problems/suicidal ideation, and enlargement of a craniopharyngioma. This article provides an update on data from the registry and briefly discusses topical and controversial issues in the treatment of pediatric patients requiring GH therapy.

Original languageEnglish (US)
Pages (from-to)702-707
Number of pages6
JournalPediatric Endocrinology Reviews
Volume5
Issue numberSUPPL. 2
StatePublished - Feb 1 2008

Keywords

  • Body mass index
  • Dose
  • GHMonitor
  • Gonadotropin releasing-hormone agonist
  • Growth hormone
  • Growth hormone deficiency
  • Insulin-like growth factor-I
  • Neuroimaging

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

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    Pitukcheewanont, P., Desrosiers, P., Steelman, J., Rapaport, R., Fuqua, J. S., Kreher, N. C., & Hamlett, A. (2008). Issues and trends in pediatric growth hormone therapy - An update from the GHMonitorSM observational registry. Pediatric Endocrinology Reviews, 5(SUPPL. 2), 702-707.