Juvenile chronic myelogenous leukemia

Jay Hess, Mary M. Zutter, Robert P. Castleberry, Peter D. Emanuel

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Juvenile chronic myelogenous leukemia (JCML) is an aggressive myeloproliferative disorder of childhood that differs both clinically and pathologically from adult type, Philadelphia chromosome positive chronic myelogenous leukemia, and from the other myeloproliferative disorders that are more common in adulthood. The disease can have widely varying clinical presentations and shares many features with the monosomy 7 syndrome and chronic myelomonocytic leukemia. With no specific marker chromosome, establishing the diagnosis can be difficult, and relies on a constellation of clinical, pathologic, and laboratory findings. This article discusses the differential diagnosis of JCML with an emphasis on the pathologic findings and laboratory data that are particularly important for confirming the diagnosis. The sensitivity, specificity, and clinical utility of cell culture colony assays are reviewed. Finally, current knowledge of the biology of JCML and some of the controversies regarding this disease are discussed.

Original languageEnglish (US)
Pages (from-to)238-248
Number of pages11
JournalAmerican Journal of Clinical Pathology
Volume105
Issue number2
StatePublished - Feb 1996
Externally publishedYes

Fingerprint

Juvenile Myelomonocytic Leukemia
Myeloproliferative Disorders
Leukemia, Myelomonocytic, Chronic
Philadelphia Chromosome
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Genetic Markers
Differential Diagnosis
Cell Culture Techniques
Sensitivity and Specificity

Keywords

  • Childhood diseases
  • Cytogenetics
  • Leukemia
  • Myeloproliferative disorders

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Hess, J., Zutter, M. M., Castleberry, R. P., & Emanuel, P. D. (1996). Juvenile chronic myelogenous leukemia. American Journal of Clinical Pathology, 105(2), 238-248.

Juvenile chronic myelogenous leukemia. / Hess, Jay; Zutter, Mary M.; Castleberry, Robert P.; Emanuel, Peter D.

In: American Journal of Clinical Pathology, Vol. 105, No. 2, 02.1996, p. 238-248.

Research output: Contribution to journalArticle

Hess, J, Zutter, MM, Castleberry, RP & Emanuel, PD 1996, 'Juvenile chronic myelogenous leukemia', American Journal of Clinical Pathology, vol. 105, no. 2, pp. 238-248.
Hess J, Zutter MM, Castleberry RP, Emanuel PD. Juvenile chronic myelogenous leukemia. American Journal of Clinical Pathology. 1996 Feb;105(2):238-248.
Hess, Jay ; Zutter, Mary M. ; Castleberry, Robert P. ; Emanuel, Peter D. / Juvenile chronic myelogenous leukemia. In: American Journal of Clinical Pathology. 1996 ; Vol. 105, No. 2. pp. 238-248.
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