KAI1 is unchanged in metastatic and nonmetastatic esophageal and gastric cancers

Xiao Zhong Guo, Helmut Friess, Christoph Maurer, Pascal Berberat, Wen Hao Tang, Arthur Zimmermann, Markus Naef, Hans U. Graber, Murray Korc, Markus W. Büchler

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Down-regulation of KAI1 mRNA expression has been shown to be associated with the formation of metastases or disease progression in pancreatic cancer. Whether KAI1 possesses similar characteristics in other malignancies of the gastrointestinal tract is not known. Here, we compared the patterns of KAI1 mRNA expression in 41 esophageal cancers and 35 stomach cancers to assess whether KAI1 might also be of biological relevance in the metastatic ability of these tumors. By Northern blot analysis, KAI1 mRNA levels ranged widely in both normal and cancerous esophageal and gastric tissue samples, with no statistical differences. No association between KAI1 mRNA expression and tumor stage or tumor differentiation was seen in these tumors. In addition, KAI1 mRNA expression was similar in primary esophageal and gastric cancer samples with or without metastases. By in situ hybridization, KAI1 mRNA expression was evident in the cytoplasm of most squamous epithelial cells in the normal esophagus and in nonmucosal epithelial cells of the normal stomach. The staining intensity in the esophageal and gastric cancer cells was similar to that in the normal controls. This differential pattern of KAI1 mRNA expression in esophageal and gastric cancers in comparison to pancreatic cancer indicates that KAI1 seems to influence the potential of gastrointestinal cancer cells to metastasize differently. In esophageal and gastric cancers, the formation of metastases is not dependent on the reduction of KAI1 in the cancer cells.

Original languageEnglish (US)
Pages (from-to)753-758
Number of pages6
JournalCancer Research
Volume58
Issue number4
StatePublished - Feb 15 1998
Externally publishedYes

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Esophageal Neoplasms
Stomach Neoplasms
Messenger RNA
Neoplasms
Neoplasm Metastasis
Pancreatic Neoplasms
Stomach
Epithelial Cells
Gastrointestinal Neoplasms
Northern Blotting
Esophagus
In Situ Hybridization
Disease Progression
Gastrointestinal Tract
Cytoplasm
Down-Regulation
Staining and Labeling

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Guo, X. Z., Friess, H., Maurer, C., Berberat, P., Tang, W. H., Zimmermann, A., ... Büchler, M. W. (1998). KAI1 is unchanged in metastatic and nonmetastatic esophageal and gastric cancers. Cancer Research, 58(4), 753-758.

KAI1 is unchanged in metastatic and nonmetastatic esophageal and gastric cancers. / Guo, Xiao Zhong; Friess, Helmut; Maurer, Christoph; Berberat, Pascal; Tang, Wen Hao; Zimmermann, Arthur; Naef, Markus; Graber, Hans U.; Korc, Murray; Büchler, Markus W.

In: Cancer Research, Vol. 58, No. 4, 15.02.1998, p. 753-758.

Research output: Contribution to journalArticle

Guo, XZ, Friess, H, Maurer, C, Berberat, P, Tang, WH, Zimmermann, A, Naef, M, Graber, HU, Korc, M & Büchler, MW 1998, 'KAI1 is unchanged in metastatic and nonmetastatic esophageal and gastric cancers', Cancer Research, vol. 58, no. 4, pp. 753-758.
Guo XZ, Friess H, Maurer C, Berberat P, Tang WH, Zimmermann A et al. KAI1 is unchanged in metastatic and nonmetastatic esophageal and gastric cancers. Cancer Research. 1998 Feb 15;58(4):753-758.
Guo, Xiao Zhong ; Friess, Helmut ; Maurer, Christoph ; Berberat, Pascal ; Tang, Wen Hao ; Zimmermann, Arthur ; Naef, Markus ; Graber, Hans U. ; Korc, Murray ; Büchler, Markus W. / KAI1 is unchanged in metastatic and nonmetastatic esophageal and gastric cancers. In: Cancer Research. 1998 ; Vol. 58, No. 4. pp. 753-758.
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