Kappa III immunoglobulin light chain origin of localized orbital amyloidosis

Kamran Hamidi Asl, Juris J. Liepnieks, William R. Nunery, Masahide Yazaki, Merrill D. Benson

Research output: Contribution to journalArticle

7 Scopus citations


Isolated orbital amyloidosis is a rare condition in which intra-muscular deposits result in proptosis and restriction of eye movement. Previous reports have suggested an immunoglobulin origin of the amyloid fibrils, but this has not been proven biochemically. A case is presented in which initial unilateral orbital amyloidosis progressed to bilateral disease. Biochemical analysis of resected ocular muscle determined that the amyloid fibrils were derived from a kappa III immunoglobulin light chain. Questions of pathogenesis and tissue tropism are considered.

Original languageEnglish (US)
Pages (from-to)179-183
Number of pages5
Issue number3
StatePublished - Sep 1 2004


  • Amyloid
  • Immunoglobulin light chain
  • Kappa
  • Ocular

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medicine(all)

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