Kidney Disease and Bone: Changing the Way We Look at Skeletal Health

Matthew R. Allen, Elizabeth A. Swallow, Corinne E. Metzger

Research output: Contribution to journalReview article

Abstract

Purpose of Review: Kidney disease imparts profound skeletal changes, and unlike many other skeletal diseases, cortical bone is predominantly impacted. Significant advances in medical imaging have led to our ability to now obtain high-resolution three-dimensional views of cortical bone. This paper overviews recent work focused on cortical bone imaging, specifically cortical porosity, in kidney disease. Recent Findings: Although a number of clinical papers have used high-resolution imaging to assess cortical bone porosity, the most impactful work involves longitudinal study designs that have assessed cortical porosity changes over time. These latter studies demonstrate dramatic increases in cortical porosity in untreated individuals and a lack of clear efficacy in reversing porosity with treatment (although data are limited). Summary: Those papers providing longitudinal assessment, both clinical and pre-clinical, reveal powerful data about cortical porosity and provide a foundation upon which future studies can build.

Original languageEnglish (US)
Pages (from-to)242-246
Number of pages5
JournalCurrent osteoporosis reports
Volume18
Issue number3
DOIs
StatePublished - Jun 1 2020

Keywords

  • CKD-MBD
  • Cortical bone
  • Cortical porosity
  • HR-pQCT
  • Imaging

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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