Kimchi and soybean pastes are risk factors of gastric cancer

Hongmei Nan, Jin Woo Park, Young Jin Song, Hyo Yung Yun, Joo Seung Park, Taisun Hyun, Sei Jin Youn, Yong Dae Kim, Jong Won Kang, Heon Kim

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Aim: This case-control study investigated the effects of kimchi, soybean paste, fresh vegetables, nonfermented alliums, nonfermented seafood, nonfermented soybean foods, and the genetic polymorphisms of some metabolic enzymes on the risk of gastric cancer in Koreans. Methods: We studied 421 gastric cancer patients and 632 age- and sex-matched controls. Subjects completed a structured questionnaire regarding their food intake pattern. Polymorphisms of cytochrome P450 1A1 (CYP1A1), cytochrome P450 2E1 (CYP2E1), glutathione S-transferase mu 1 (GSTM1), glutathione S-transferase theta 1 (GSTT1) and aldehyde dehydrogenase 2 (ALDH2) were investigated. Results: A decreased risk of gastric cancer was noted among people with high consumption of nonfermented alliums and nonfermented seafood. On the other hand, consumption of kimchi, and soybean pastes was associated with increased risk of gastric cancer. Individuals with the CYP1A1 Ile/Val or Val/Val genotype showed a significantly increased risk for gastric cancer. Increased intake of kimchi or soybean pastes was a significant risk factor for the CYP1A1 Ile/Ile, the CYP2E1 c1/c1, the GSTM1 non-null, the GSTT1 non-null, or the ALDH2 *1/*1 genotype. In addition, eating soybean pastes was associated with the increased risk of gastric cancer in individuals with the GSTM1 null type. Nonfermented alliums were significant in individuals with the CYP1A1 Ile/Ile, the CYP2E1 c1/c2 or c2/c2, the GSTT1 null, the GSTT1 non-null, or the ALDH2 *1/*2 or *2/*2 genotype, nonfermented seafood was those with the CYP1A1 Ile/Ile, the CYP2E1 c1 /c1, the ALDH2 *1/*1 genotype or any type of GSTM1 or GSTT1. In homogeneity tests, the odds ratios of eating kimchi for gastric cancer according to the GSTM1 or GSTT1 genotype were not homogeneous. Conclusion: Kimchi, soybean pastes, and the CYP1A1 Ile/Val or Val/Val are risk factors, and nonfermented seafood and alliums are protective factors against gastric cancer in Koreans. Salt or some chemicals contained in kimchi and soybean pastes, which are increased by fermentation, would play important roles in the carcinogenesis of stomach cancer. Polymorphisms of the CYP1A1, CYP2E1, GSTM1, GSTT1, and ALDH2 genes could modify the effects of some environmental factors on the risk of gastric cancer.

Original languageEnglish (US)
Pages (from-to)3175-3181
Number of pages7
JournalWorld Journal of Gastroenterology
Volume11
Issue number21
StatePublished - Jun 7 2005
Externally publishedYes

Fingerprint

Ointments
Glutathione Transferase
Soybeans
Stomach Neoplasms
Cytochrome P-450 Enzyme System
Cytochrome P-450 CYP2E1
Seafood
Genotype
Aldehyde Dehydrogenase
Eating
Genetic Polymorphisms
glutathione S-transferase T1
Vegetables
Fermentation
Case-Control Studies
Carcinogenesis
Salts
Odds Ratio
Food

Keywords

  • Gastric cancer
  • Kimchi
  • Soybean pastes

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Nan, H., Park, J. W., Song, Y. J., Yun, H. Y., Park, J. S., Hyun, T., ... Kim, H. (2005). Kimchi and soybean pastes are risk factors of gastric cancer. World Journal of Gastroenterology, 11(21), 3175-3181.

Kimchi and soybean pastes are risk factors of gastric cancer. / Nan, Hongmei; Park, Jin Woo; Song, Young Jin; Yun, Hyo Yung; Park, Joo Seung; Hyun, Taisun; Youn, Sei Jin; Kim, Yong Dae; Kang, Jong Won; Kim, Heon.

In: World Journal of Gastroenterology, Vol. 11, No. 21, 07.06.2005, p. 3175-3181.

Research output: Contribution to journalArticle

Nan, H, Park, JW, Song, YJ, Yun, HY, Park, JS, Hyun, T, Youn, SJ, Kim, YD, Kang, JW & Kim, H 2005, 'Kimchi and soybean pastes are risk factors of gastric cancer', World Journal of Gastroenterology, vol. 11, no. 21, pp. 3175-3181.
Nan H, Park JW, Song YJ, Yun HY, Park JS, Hyun T et al. Kimchi and soybean pastes are risk factors of gastric cancer. World Journal of Gastroenterology. 2005 Jun 7;11(21):3175-3181.
Nan, Hongmei ; Park, Jin Woo ; Song, Young Jin ; Yun, Hyo Yung ; Park, Joo Seung ; Hyun, Taisun ; Youn, Sei Jin ; Kim, Yong Dae ; Kang, Jong Won ; Kim, Heon. / Kimchi and soybean pastes are risk factors of gastric cancer. In: World Journal of Gastroenterology. 2005 ; Vol. 11, No. 21. pp. 3175-3181.
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AU - Nan, Hongmei

AU - Park, Jin Woo

AU - Song, Young Jin

AU - Yun, Hyo Yung

AU - Park, Joo Seung

AU - Hyun, Taisun

AU - Youn, Sei Jin

AU - Kim, Yong Dae

AU - Kang, Jong Won

AU - Kim, Heon

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N2 - Aim: This case-control study investigated the effects of kimchi, soybean paste, fresh vegetables, nonfermented alliums, nonfermented seafood, nonfermented soybean foods, and the genetic polymorphisms of some metabolic enzymes on the risk of gastric cancer in Koreans. Methods: We studied 421 gastric cancer patients and 632 age- and sex-matched controls. Subjects completed a structured questionnaire regarding their food intake pattern. Polymorphisms of cytochrome P450 1A1 (CYP1A1), cytochrome P450 2E1 (CYP2E1), glutathione S-transferase mu 1 (GSTM1), glutathione S-transferase theta 1 (GSTT1) and aldehyde dehydrogenase 2 (ALDH2) were investigated. Results: A decreased risk of gastric cancer was noted among people with high consumption of nonfermented alliums and nonfermented seafood. On the other hand, consumption of kimchi, and soybean pastes was associated with increased risk of gastric cancer. Individuals with the CYP1A1 Ile/Val or Val/Val genotype showed a significantly increased risk for gastric cancer. Increased intake of kimchi or soybean pastes was a significant risk factor for the CYP1A1 Ile/Ile, the CYP2E1 c1/c1, the GSTM1 non-null, the GSTT1 non-null, or the ALDH2 *1/*1 genotype. In addition, eating soybean pastes was associated with the increased risk of gastric cancer in individuals with the GSTM1 null type. Nonfermented alliums were significant in individuals with the CYP1A1 Ile/Ile, the CYP2E1 c1/c2 or c2/c2, the GSTT1 null, the GSTT1 non-null, or the ALDH2 *1/*2 or *2/*2 genotype, nonfermented seafood was those with the CYP1A1 Ile/Ile, the CYP2E1 c1 /c1, the ALDH2 *1/*1 genotype or any type of GSTM1 or GSTT1. In homogeneity tests, the odds ratios of eating kimchi for gastric cancer according to the GSTM1 or GSTT1 genotype were not homogeneous. Conclusion: Kimchi, soybean pastes, and the CYP1A1 Ile/Val or Val/Val are risk factors, and nonfermented seafood and alliums are protective factors against gastric cancer in Koreans. Salt or some chemicals contained in kimchi and soybean pastes, which are increased by fermentation, would play important roles in the carcinogenesis of stomach cancer. Polymorphisms of the CYP1A1, CYP2E1, GSTM1, GSTT1, and ALDH2 genes could modify the effects of some environmental factors on the risk of gastric cancer.

AB - Aim: This case-control study investigated the effects of kimchi, soybean paste, fresh vegetables, nonfermented alliums, nonfermented seafood, nonfermented soybean foods, and the genetic polymorphisms of some metabolic enzymes on the risk of gastric cancer in Koreans. Methods: We studied 421 gastric cancer patients and 632 age- and sex-matched controls. Subjects completed a structured questionnaire regarding their food intake pattern. Polymorphisms of cytochrome P450 1A1 (CYP1A1), cytochrome P450 2E1 (CYP2E1), glutathione S-transferase mu 1 (GSTM1), glutathione S-transferase theta 1 (GSTT1) and aldehyde dehydrogenase 2 (ALDH2) were investigated. Results: A decreased risk of gastric cancer was noted among people with high consumption of nonfermented alliums and nonfermented seafood. On the other hand, consumption of kimchi, and soybean pastes was associated with increased risk of gastric cancer. Individuals with the CYP1A1 Ile/Val or Val/Val genotype showed a significantly increased risk for gastric cancer. Increased intake of kimchi or soybean pastes was a significant risk factor for the CYP1A1 Ile/Ile, the CYP2E1 c1/c1, the GSTM1 non-null, the GSTT1 non-null, or the ALDH2 *1/*1 genotype. In addition, eating soybean pastes was associated with the increased risk of gastric cancer in individuals with the GSTM1 null type. Nonfermented alliums were significant in individuals with the CYP1A1 Ile/Ile, the CYP2E1 c1/c2 or c2/c2, the GSTT1 null, the GSTT1 non-null, or the ALDH2 *1/*2 or *2/*2 genotype, nonfermented seafood was those with the CYP1A1 Ile/Ile, the CYP2E1 c1 /c1, the ALDH2 *1/*1 genotype or any type of GSTM1 or GSTT1. In homogeneity tests, the odds ratios of eating kimchi for gastric cancer according to the GSTM1 or GSTT1 genotype were not homogeneous. Conclusion: Kimchi, soybean pastes, and the CYP1A1 Ile/Val or Val/Val are risk factors, and nonfermented seafood and alliums are protective factors against gastric cancer in Koreans. Salt or some chemicals contained in kimchi and soybean pastes, which are increased by fermentation, would play important roles in the carcinogenesis of stomach cancer. Polymorphisms of the CYP1A1, CYP2E1, GSTM1, GSTT1, and ALDH2 genes could modify the effects of some environmental factors on the risk of gastric cancer.

KW - Gastric cancer

KW - Kimchi

KW - Soybean pastes

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