Kin I Kinesins: Insights into the Mechanism of Depolymerization

Kathleen M. Hertzer, Stephanie C. Ems-McClung, Claire E. Walczak

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

Kin I kinesins are members of the diverse kinesin superfamily of molecular motors. Whereas most kinesins use ATP to move along microtubules, Kin I kinesins depolymerize microtubules rather than walk along them. Functionally, this distinct subfamily of kinesins is important in regulating cellular microtubule dynamics and plays a crucial role in spindle assembly and chromosome segregation. The molecular mechanism of Kin I-induced microtubule destabilization is as yet unclear. It is generally believed that Kin Is induce a structural change on the microtubule that leads to microtubule destabilization. Recently, much progress has been made towards understanding how Kin Is may cause this structural change, and how ATPase activity is employed in the catalytic cycle.

Original languageEnglish (US)
Pages (from-to)453-469
Number of pages17
JournalCritical Reviews in Biochemistry and Molecular Biology
Volume38
Issue number6
DOIs
StatePublished - Dec 1 2003

Keywords

  • Microtubule dynamics
  • Mitosis
  • Molecular motor proteins

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry

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