Kinematic modeling and its implication in longitudinal chemotherapy study of tumor physiology: Ovarian xenograft mouse model and contrast-enhanced dynamic CT

Keith M. Stantz, Yun Liang, Gary Hutchins

Research output: Chapter in Book/Report/Conference proceedingConference contribution

8 Scopus citations

Abstract

The study was conducted to demonstrate that dynamic Computer Tomography (CT) provides necessary sensitivity to quantify tumor physiology and differences in chemotherapeutic reponse. A compartmental mouse model utilizing measured contrast-enhanced dynamic CT scans was used to simulate systematic and statistical errors associated with tumor physiology. Two sets of simulations were performed quantifying the relationship between scanner temporal resolution and contrast media injection rates for various tumor permeabilities. The tests confirm that in both cases dynamic CT provides the necessary sensitivity to distinguish between the differing therapeutic reponses of proteasome and inosine monophasphate dehydrogenase (IMPDH) inhibitors.

Original languageEnglish
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsA.A. Amini, A. Mandura
Pages769-779
Number of pages11
Volume5369
DOIs
StatePublished - 2004
EventMedical Imaging 2004: Physiology, Function, and Structure from Medical Images - San Diego, CA, United States
Duration: Feb 15 2004Feb 17 2004

Other

OtherMedical Imaging 2004: Physiology, Function, and Structure from Medical Images
CountryUnited States
CitySan Diego, CA
Period2/15/042/17/04

Keywords

  • Compartmental model
  • Dynamic computed tomography
  • Statistical error
  • Systematic error
  • Tumor physiology

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Fingerprint Dive into the research topics of 'Kinematic modeling and its implication in longitudinal chemotherapy study of tumor physiology: Ovarian xenograft mouse model and contrast-enhanced dynamic CT'. Together they form a unique fingerprint.

  • Cite this

    Stantz, K. M., Liang, Y., & Hutchins, G. (2004). Kinematic modeling and its implication in longitudinal chemotherapy study of tumor physiology: Ovarian xenograft mouse model and contrast-enhanced dynamic CT. In A. A. Amini, & A. Mandura (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 5369, pp. 769-779) https://doi.org/10.1117/12.536212