Kinesin-13s in mitosis: Key players in the spatial and temporal organization of spindle microtubules

Stephanie C. Ems-McClung, Claire E. Walczak

Research output: Contribution to journalReview article

86 Scopus citations

Abstract

Dynamic microtubules are essential for the process of mitosis. Thus, elucidating when, where, and how microtubule dynamics are regulated is key to understanding this process. One important class of proteins that directly regulates microtubule dynamics is the Kinesin-13 family. Kinesin-13 proteins induce depolymerization uniquely from both ends of the microtubule. This activity coincides with their cellular localization and with their ability to regulate microtubule dynamics to control spindle assembly and kinetochore-microtubule attachments. In this review, we highlight recent findings that dissect the important actions of Kinesin-13 family members and summarize important studies on the regulation of their activity by phosphorylation and by protein-protein interactions.

Original languageEnglish (US)
Pages (from-to)276-282
Number of pages7
JournalSeminars in Cell and Developmental Biology
Volume21
Issue number3
DOIs
StatePublished - May 2010

Keywords

  • Kinesin-13
  • Kinetochore-microtubule attachments
  • Microtubule dynamics
  • Phosphorylation
  • Protein-protein interaction
  • Spindle assembly

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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