Klinefelter's syndrome associated with mediastinal germ cell neoplasms.

C. R. Nichols, N. A. Heerema, C. Palmer, Patrick Loehrer, S. D. Williams, Lawrence Einhorn

Research output: Contribution to journalArticle

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Abstract

Several case reports have suggested an association of primary mediastinal germ cell tumor (PMGCT) and Klinefelter's syndrome (KS). In an effort to confirm this association, 22 patients with mediastinal germ cell tumors had chromosome studies performed in a prospective fashion. Five patients (22%) had karyotypic or pathologic evidence of KS. All of the patients with KS had germ cell tumors of the nonseminomatous subtype and were relatively young (median age, 15 years). The literature confirms the findings of a young median age (18 years), nonseminomatous subtype, and mediastinal location of the germ cell neoplasm. We conclude that patients with KS are predisposed to the development of mediastinal nonseminomatous germ cell cancers.

Original languageEnglish
Pages (from-to)1290-1294
Number of pages5
JournalJournal of Clinical Oncology
Volume5
Issue number8
StatePublished - Aug 1987
Externally publishedYes

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Mediastinal Neoplasms
Klinefelter Syndrome
Germ Cell and Embryonal Neoplasms
Chromosomes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Nichols, C. R., Heerema, N. A., Palmer, C., Loehrer, P., Williams, S. D., & Einhorn, L. (1987). Klinefelter's syndrome associated with mediastinal germ cell neoplasms. Journal of Clinical Oncology, 5(8), 1290-1294.

Klinefelter's syndrome associated with mediastinal germ cell neoplasms. / Nichols, C. R.; Heerema, N. A.; Palmer, C.; Loehrer, Patrick; Williams, S. D.; Einhorn, Lawrence.

In: Journal of Clinical Oncology, Vol. 5, No. 8, 08.1987, p. 1290-1294.

Research output: Contribution to journalArticle

Nichols, CR, Heerema, NA, Palmer, C, Loehrer, P, Williams, SD & Einhorn, L 1987, 'Klinefelter's syndrome associated with mediastinal germ cell neoplasms.', Journal of Clinical Oncology, vol. 5, no. 8, pp. 1290-1294.
Nichols, C. R. ; Heerema, N. A. ; Palmer, C. ; Loehrer, Patrick ; Williams, S. D. ; Einhorn, Lawrence. / Klinefelter's syndrome associated with mediastinal germ cell neoplasms. In: Journal of Clinical Oncology. 1987 ; Vol. 5, No. 8. pp. 1290-1294.
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