Knowledge Gaps and Research Priorities in Immune Checkpoint Inhibitor–related Pneumonitis An Official American Thoracic Society Research Statement

Catherine R. Sears, M. Patricia Rivera, Philippe Camus, Mina Gaga, Edward B. Garon, Michael K. Gould, Andrew H. Limper, Philippe R. Montgrain, Jarushka Naidoo, Mizuki Nishino, Sandip P. Patel, Tobias Peikert, Jennifer D. Possick, William D. Travis

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Rationale: Immune checkpoint inhibitors (ICIs) have revolutionized cancer care but are associated with unique adverse events, including potentially life-threatening pneumonitis. The diagnosis of ICI-pneumonitis is increasing; however, the biological mechanisms, clinical and radiologic features, and the diagnosis and management have not been well defined. Objectives: To summarize evidence, identify knowledge and research gaps, and prioritize topics and propose methods for future research on ICI-pneumonitis. Methods: A multidisciplinary group of international clinical researchers reviewed available data on ICI-pneumonitis to develop and refine research questions pertaining to ICI-pneumonitis. Results: This statement identifies gaps in knowledge and develops potential research questions to further expand knowledge regarding risk, biologic mechanisms, clinical and radiologic presentation, and management of ICI-pneumonitis. Conclusions: Gaps in knowledge of the basic biological mechanisms of ICI-pneumonitis, coupled with a precipitous increase in the use of ICIs alone or combined with other therapies, highlight the importance in triaging research priorities for ICI-pneumonitis.

Original languageEnglish (US)
Pages (from-to)E31-E43
JournalAmerican journal of respiratory and critical care medicine
Volume200
Issue number6
DOIs
StatePublished - Sep 15 2019

Keywords

  • Immunotherapy
  • Interstitial lung disease
  • Lung cancer
  • NSCLC

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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    Sears, C. R., Rivera, M. P., Camus, P., Gaga, M., Garon, E. B., Gould, M. K., Limper, A. H., Montgrain, P. R., Naidoo, J., Nishino, M., Patel, S. P., Peikert, T., Possick, J. D., & Travis, W. D. (2019). Knowledge Gaps and Research Priorities in Immune Checkpoint Inhibitor–related Pneumonitis An Official American Thoracic Society Research Statement. American journal of respiratory and critical care medicine, 200(6), E31-E43. https://doi.org/10.1164/rccm.201906-1202ST