L-Asparaginase delivered by Salmonella typhimurium suppresses solid tumors

Kwangsoo Kim, Jae Ho Jeong, Daejin Lim, Yeongjin Hong, Hyung Ju Lim, Geun Joong Kim, So Ra Shin, Je Jung Lee, Misun Yun, Robert A. Harris, Jung Joon Min, Hyon E. Choy

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Bacteria can be engineered to deliver anticancer proteins to tumors via a controlled expression system that maximizes the concentration of the therapeutic agent in the tumor. L-asparaginase (L-ASNase), which primarily converts asparagine to aspartate, is an anticancer protein used to treat acute lymphoblastic leukemia. In this study, Salmonellae were engineered to express L-ASNase selectively within tumor tissues using the inducible araBAD promoter system of Escherichia coli. Antitumor efficacy of the engineered bacteria was demonstrated in vivo in solid malignancies. This result demonstrates the merit of bacteria as cancer drug delivery vehicles to administer cancer-starving proteins such as L-ASNase to be effective selectively within the microenvironment of cancer tissue.

Original languageEnglish (US)
Article number15007
Number of pages1
JournalMolecular Therapy - Oncolytics
Volume2
DOIs
StatePublished - Jun 10 2015

ASJC Scopus subject areas

  • Molecular Medicine
  • Oncology
  • Cancer Research
  • Pharmacology (medical)

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    Kim, K., Jeong, J. H., Lim, D., Hong, Y., Lim, H. J., Kim, G. J., Shin, S. R., Lee, J. J., Yun, M., Harris, R. A., Min, J. J., & Choy, H. E. (2015). L-Asparaginase delivered by Salmonella typhimurium suppresses solid tumors. Molecular Therapy - Oncolytics, 2, [15007]. https://doi.org/10.1038/mto.2015.7