Label-free quantitative imaging of cholesterol in intact tissues by hyperspectral stimulated Raman scattering microscopy

Ping Wang, Junjie Li, Pu Wang, Chun Rui Hu, Delong Zhang, Michael Sturek, Ji Xin Cheng

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

A finger on the pulse: Current molecular analysis of cells and tissues routinely relies on separation, enrichment, and subsequent measurements by various assays. Now, a platform of hyperspectral stimulated Raman scattering microscopy has been developed for the fast, quantitative, and label-free imaging of biomolecules in intact tissues using spectroscopic fingerprints as the contrast mechanism.

Original languageEnglish (US)
Pages (from-to)13042-13046
Number of pages5
JournalAngewandte Chemie - International Edition
Volume52
Issue number49
DOIs
StatePublished - Dec 2 2013

Keywords

  • cholesterol
  • lipids
  • stimulated Raman scattering
  • tissue analysis
  • vibrational spectroscopy

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

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