Lack of an association between apolipoprotein E ϵ4 and Alzheimer's disease in elderly nigerians

B. O. Osuntokun, A. Sahota, A. O. Ogunniyi, O. Gureje, O. Baiyewu, A. Adeyinka, S. O. Oluwole, O. Komolafe, K. S. Hall, F. W. Unverzagt, S. L. Hui, M. Yang, H. C. Hendrie

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133 Scopus citations

Abstract

As part of a community-based study of Alzheimer's Disease (AD) in a Nigerian population aged 65 years and over, we have determined apolipoprotein E (APOE) genotypes on 56 subjects (39 controls and 17 subjects with dementia, including 12 with AD). The ε4 allele of APOE was not associated with AD or dementia in this community-based sample. The ε4 allele frequency was 17.6% in demented patients and 16.7% in AD patients compared with 20.5% in the control subjects. These findings are in marked contrast to the strong association between the ε4 allele and AD in our previously reported study with African Americans.

Original languageEnglish (US)
Pages (from-to)463-465
Number of pages3
JournalAnnals of Neurology
Volume38
Issue number3
DOIs
StatePublished - Sep 1995

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Osuntokun, B. O., Sahota, A., Ogunniyi, A. O., Gureje, O., Baiyewu, O., Adeyinka, A., Oluwole, S. O., Komolafe, O., Hall, K. S., Unverzagt, F. W., Hui, S. L., Yang, M., & Hendrie, H. C. (1995). Lack of an association between apolipoprotein E ϵ4 and Alzheimer's disease in elderly nigerians. Annals of Neurology, 38(3), 463-465. https://doi.org/10.1002/ana.410380319