Objective: The authors' goal was to determine whether either of two 5- HT(2A) receptor polymorphisms, 102-T/C and 452-His/Tyr, are associated with clozapine response. Method: Brief Psychiatric Rating Scale (BPRS) ratings were obtained for 70 patients with schizophrenia or schizoaffective disorder to determine their response to clozapine compared with a typical neuroleptic. Patients were genotyped with the polymerase chain reaction and restriction fragment length polymorphism analysis. Results: Neither 102-T/C nor 452-His/Tyr was associated with clozapine response. There were no significant differences in BPRS scores among patients with different 5- HT(2A) genotypes at week 10 of clozapine administration. Conclusions: Allelic variation in the 5-HT(2A) gene is not associated with individual differences in clozapine response.
ASJC Scopus subject areas
- Psychiatry and Mental health