Lack of association between polymorphisms in the 5-HT(2A) receptor gene and the antipsychotic response to clozapine

Anil K. Malhotra, David Goldman, Norio Ozaki, Alan Breier, Robert Buchanan, David Pickar

Research output: Contribution to journalArticle

101 Scopus citations

Abstract

Objective: The authors' goal was to determine whether either of two 5- HT(2A) receptor polymorphisms, 102-T/C and 452-His/Tyr, are associated with clozapine response. Method: Brief Psychiatric Rating Scale (BPRS) ratings were obtained for 70 patients with schizophrenia or schizoaffective disorder to determine their response to clozapine compared with a typical neuroleptic. Patients were genotyped with the polymerase chain reaction and restriction fragment length polymorphism analysis. Results: Neither 102-T/C nor 452-His/Tyr was associated with clozapine response. There were no significant differences in BPRS scores among patients with different 5- HT(2A) genotypes at week 10 of clozapine administration. Conclusions: Allelic variation in the 5-HT(2A) gene is not associated with individual differences in clozapine response.

Original languageEnglish (US)
Pages (from-to)1092-1094
Number of pages3
JournalAmerican Journal of Psychiatry
Volume153
Issue number8
DOIs
StatePublished - Aug 1996
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health

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