Lack of association between polymorphisms in the 5-HT(2A) receptor gene and the antipsychotic response to clozapine

Anil K. Malhotra, David Goldman, Norio Ozaki, Alan Breier, Robert Buchanan, David Pickar

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

Objective: The authors' goal was to determine whether either of two 5- HT(2A) receptor polymorphisms, 102-T/C and 452-His/Tyr, are associated with clozapine response. Method: Brief Psychiatric Rating Scale (BPRS) ratings were obtained for 70 patients with schizophrenia or schizoaffective disorder to determine their response to clozapine compared with a typical neuroleptic. Patients were genotyped with the polymerase chain reaction and restriction fragment length polymorphism analysis. Results: Neither 102-T/C nor 452-His/Tyr was associated with clozapine response. There were no significant differences in BPRS scores among patients with different 5- HT(2A) genotypes at week 10 of clozapine administration. Conclusions: Allelic variation in the 5-HT(2A) gene is not associated with individual differences in clozapine response.

Original languageEnglish (US)
Pages (from-to)1092-1094
Number of pages3
JournalAmerican Journal of Psychiatry
Volume153
Issue number8
StatePublished - Aug 1996
Externally publishedYes

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Receptor, Serotonin, 5-HT2A
Clozapine
Antipsychotic Agents
Brief Psychiatric Rating Scale
Genes
Serotonin
Individuality
Restriction Fragment Length Polymorphisms
Psychotic Disorders
Schizophrenia
Genotype
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Lack of association between polymorphisms in the 5-HT(2A) receptor gene and the antipsychotic response to clozapine. / Malhotra, Anil K.; Goldman, David; Ozaki, Norio; Breier, Alan; Buchanan, Robert; Pickar, David.

In: American Journal of Psychiatry, Vol. 153, No. 8, 08.1996, p. 1092-1094.

Research output: Contribution to journalArticle

Malhotra, Anil K. ; Goldman, David ; Ozaki, Norio ; Breier, Alan ; Buchanan, Robert ; Pickar, David. / Lack of association between polymorphisms in the 5-HT(2A) receptor gene and the antipsychotic response to clozapine. In: American Journal of Psychiatry. 1996 ; Vol. 153, No. 8. pp. 1092-1094.
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AU - Pickar, David

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