Lack of association between the interleukin-1 alpha (-889) polymorphism and early-onset Parkinson's disease

Jens Carsten Möller, Candan Depboylu, Heike Kölsch, Frank Lohmüller, Oliver Bandmann, Petra Gocke, Yansheng Du, Sebastian Paus, Ullrich Wüllner, Thomas Gasser, Wolfgang H. Oertel, Thomas Klockgether, Richard C. Dodel

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

An increasing number of studies have shown that an inflammatory process is part of Parkinson's disease (PD) brain pathology. Interleukin-1 (IL-1) is a multifunctional cytokine and is considered to contribute to several inflammatory diseases. Recently, we detected an associated risk in a subgroup of PD patients with a disease onset <50 years and a C to T transition in the IL-1α promoter (-889). One-hundred-seventy-six German PD patients (42.1±6.4 years; 42.4% male) and 170 unrelated age-matched control individuals (40.4±8.7 years; 57.6% male) were investigated for the presence of the IL-1α (-889C/T) polymorphism. No significant difference in the allelic distribution of the analyzed IL-1α polymorphism has been found between PD and controls. We conclude that the C/T polymorphism in the IL-1α promoter region at -889 does not increase the risk to develop PD.

Original languageEnglish (US)
Pages (from-to)195-197
Number of pages3
JournalNeuroscience Letters
Volume359
Issue number3
DOIs
StatePublished - Apr 15 2004

Keywords

  • Genes
  • Inflammation
  • Interleukins
  • Parkinson's disease

ASJC Scopus subject areas

  • Neuroscience(all)

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    Möller, J. C., Depboylu, C., Kölsch, H., Lohmüller, F., Bandmann, O., Gocke, P., Du, Y., Paus, S., Wüllner, U., Gasser, T., Oertel, W. H., Klockgether, T., & Dodel, R. C. (2004). Lack of association between the interleukin-1 alpha (-889) polymorphism and early-onset Parkinson's disease. Neuroscience Letters, 359(3), 195-197. https://doi.org/10.1016/j.neulet.2004.01.058